Clinical Research and Mentoring in Oral Epidemiology

口腔流行病学临床研究和指导

• 批准号: 7676204
• 负责人: KAUMUDI J JOSHIPURA
• 金额: $ 15.41万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676204
• 关键词: Adherence; Antioxidants; Area; Award; Biological Markers; Blood; Budgets; Cardiovascular Diseases; Cardiovascular system; Chronic Disease; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Complement; Congestive Heart Failure; Dental; Dental Epidemiology; Dental Schools; Dentists; Development; Diabetes Mellitus; Dietary Fiber; Environment; Epidemiologic Studies; Epidemiology; Ethnic group; Evaluation of Risk Factors; Familiarity; Fluorides; Freedom; Funding; Goals; Grant; Guidelines; Head; Health Policy; Hemostatic Agents; India; Individual; Inflammatory; Institution; Intake; Internal Medicine; Journals; K-Series Research Career Programs; Learning; Letters; Malignant Neoplasms; Manuscripts; Mediating; Mediator of activation protein; Medicine; Mentors; Methods; Mid-Career Clinical Scientist Award (K24); Molecular Epidemiology; Molecular Genetics; Mouth Diseases; New England; Nursing Faculty; Obesity; Oral; Oral health; Pathway interactions; Periodontal Diseases; Physicians; Play; Policies; Pregnancy Outcome; Principal Investigator; Public Health Schools; Publications; Publishing Peer Reviews; Qualifying; Research; Research Design; Research Personnel; Research Project Grants; Research Proposals; Research Support; Role; Running; Staging; Students; Systemic disease; Time; Tooth Loss; Training; Training Programs; United States National Institutes of Health; Universities; Work; Writing; career; career development; cohort; dental surgery; experience; genetic epidemiology; inflammatory marker; interest; nutrition; oral condition; patient oriented; patient oriented research; professor; programs; racial and ethnic; research facility; skills

DESCRIPTION (provided by applicant): The principal investigator's career has emphasized patient oriented research in Oral Epidemiology ranging from evaluation of risk factors, to mechanistic studies evaluating pathways, to clinical trials. Her ongoing funded research focuses on the relationships between oral conditions, inflammatory markers, nutrition and specific cardiovascular diseases. She has expanded this work to include additional cardiovascular endpoints and pregnancy outcomes, and is starting to work in diabetes. The principal investigator plans to gain additional research skills by learning Molecular and Genetic Epidemiology, which would substantially enhance her research. The principal investigator co-directs the comprehensive T32 training grant titled "New England Oral Disease Epidemiology Training Program" which is run jointly across the Harvard School of Dental Medicine and Harvard School of Public Health. The K24 award will nicely complement the T32 by providing the protected time to enhance mentoring. The principal investigator has substantial experience in mentoring trainees at different stages including students in the DMD program, clinicians seeking a doctoral degree in Epidemiology, and junior clinical faculty. These activities have resulted in a NIH small grant and a K-award headed by her mentees, and 21 peer reviewed published manuscripts with her mentees. This midcareer investigator award will allow the principal investigator to spend more time in mentoring and retaining clinicians (dentists as well as some physicians) in Oral Epidemiology research, and in helping them to become independent clinical researchers. There is a strong institutional commitment and a growing pool of clinicians seeking training and mentoring in Oral Epidemiology. The K24 will thus provide the much needed protected time and support at a critical time, which will enable her to build a strong research program in oral and systemic disease with an excellent team of patient oriented researchers, whom the principal investigator mentors. Candidate: Dr. Joshipura is an Associate Professor on Oral Health Policy and Epidemiology at the Harvard School of Dental Medicine, and an Associate Professor in Epidemiology at the Harvard School of Public Health. She received a degree in dental surgery from Bombay University, India in 1982, a MS in Biostastics from the Harvard School of Public Health in 1982, and ScD in Epidemiology from the Harvard School of Dental Medicine and Harvard School of Public Health. She has an impressive list of publications in leading journals including JAMA, New England J Med, JNCI, Annals of Internal Medicine as well as the leading dental journals. She has an impressive track record of funded research in the area of chronic diseases, pregnancy outcomes, and periodontal disease. The candidate documented the ability to provide mentoring to beginning clinical investigators by listing 21 students to whom she has provided a mentoring role. Most, but not all, of these mentored individuals where dentists. The types of research have varied widely and include molecular epidemiology, periodontal disease and blood biomarkers, fluoride, cancer, obesity, and other topics. Her long-term career goal is built a research program in oral and systemic disease with a strong team of collaborators and mentees. There are enthusiastic letters of commitment from the Dean of Harvard School of Dental Medicine (Dr. Bruce Donoff) who provides a commitment that she will be able to spend at least 50% on patient-oriented research, a letter from Dr. Douglass who recommends her without qualifications, and Dr. Stampfer who similarly enthusiastically supports Dr. Joshipura and indicates the she plays a major role in the Oral Epidemiology training program. Research Plan: With respect to the currently supported research, Dr. Joshipura provides enough information in the areas of the hypotheses and the specific aims, background, significance and rationale, preliminary studies and results, research designs and methods. Her specific aims are to relate dental status to systemic disease, to determine the extent to which the systemic disease-dental status association is mediated by inflammatory and hemostatic mediators, and by intake of dietary fiber and antioxidants. Different cohorts in which these aims can be assessed are listed and the investigator has extensive familiarity with these cohorts as is exemplified by her publications. She provides as an example of one specific project where the association between periodontal disease and tooth loss was investigated. For this specific project she lists the specific aims, background, significance and rationale, preliminary studies and results, research designs and methods. It appears that no new research to be specifically supported by this grant is listed because Dr. Joshipura feels strongly that mentees should have the freedom to choose their thesis topics as well as additional projects to the extent feasible. Mentors: The availability of beginning clinician investigators for mentoring is described and includes T32 trainees. Individuals from underrepresented racial/ethnic groups will be specifically targeted for recruitment. The types of educational experiences the candidate will provide include selecting of appropriate course work, identification of a research project and a research mentor, guidance with respect to preparing for the written and oral qualifying exams, and make the trainee familiar with administrative policies and adherence to administrative guidelines. Environment and Institutional Commitment: The letters of support indicate a commitment to the scientific development of the candidate, an adequacy of research facilities, a provision of adequate protected time, and a commitment of the institution towards career development. Budget: No concerns

描述（由申请人提供）：首席研究员的职业生涯一直强调以患者为导向的口腔流行病学研究，从评估风险因素，到评估途径的机制研究，再到临床试验。她正在进行的资助研究主要集中在口腔状况，炎症标志物，营养和特定心血管疾病之间的关系。她已经将这项工作扩展到包括额外的心血管终点和妊娠结局，并开始在糖尿病方面开展工作。首席研究员计划通过学习分子和遗传流行病学来获得额外的研究技能，这将大大加强她的研究。首席研究员共同指导了一项名为“新英格兰口腔疾病流行病学培训计划”的T32培训补助金，该计划由哈佛大学牙科医学院和哈佛大学公共卫生学院联合开展。K24奖励将通过提供受保护的时间来加强指导，很好地补充T32。首席研究员在指导不同阶段的受训者方面有丰富的经验，包括DMD项目的学生、寻求流行病学博士学位的临床医生和初级临床教师。这些活动为她的学生获得了NIH的小额资助和k奖，并与她的学生一起发表了21篇同行评议的手稿。这项职业中期研究者奖将允许首席研究者花更多的时间指导和留住临床医生（牙医以及一些内科医生）进行口腔流行病学研究，并帮助他们成为独立的临床研究者。有一个强有力的机构承诺和越来越多的临床医生寻求培训和指导在口腔流行病学。因此，K24将在关键时刻提供急需的保护时间和支持，这将使她能够在以患者为导向的优秀研究团队中建立一个强大的口腔和全身性疾病研究项目，这些研究团队由首席研究员指导。