Neurobiological and Behavioral Substrates of Mood Disorders

本次申请职业生涯中期调查员奖的主要目的是 面向研究“(POR)是为了支持在以下领域发展先进专业知识 神经成像和认知神经科学，以便更准确地检查 病理生理学中情绪、认知与神经元连接的关系 情绪障碍。一个平行的目标是让申请者阿南德·库马尔继续 指导POR的初级调查人员，两个机构都是在主办机构--加州大学 加州、洛杉矶(加州大学洛杉矶分校)和全国。申请人将使用磁力 磁共振成像(MRI)相关方法，如磁共振 波谱(MRS)和弥散张量成像(DTI)表征和 系统研究脑白质损伤和连接性受损在情绪中的作用 精神错乱。此外，他还将获得研究认知相关性的专业知识。 情绪障碍与综合神经心理学和神经影像学测量 为了全面评价神经元回路在病理生理学中的地位 情绪障碍。申请者还将继续投入时间指导青少年 POR的研究人员，特别是与中老年情绪障碍有关的人。这个 申请者的科学目标、目的和职业轨迹构成了K24机制 最适合他在医学学术领域的进一步成长和发展。

The primary objective of this application for a mid-career investigator award in "patient oriented research" (POR) is to support the development of advanced expertise in neuroimaging and cognitive neuroscience in order to more precisely examine the relationship between mood, cognition and neuronal connectivity in the pathophysiology of mood disorders. A parallel objective is for the applicant, Anand Kumar, to continue to mentor junior investigators in POR, both within the host institution, the University of California, Los Angeles (UCLA) and nationally. The applicant will use magnetic resonance imaging (MRI) related approaches such as magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) to characterize and systematically study the role of white matter injury and impaired connectivity in mood disorders. In addition, he will gain expertise in examining the cognitive correlates of mood disorders and integrating neuropsychological and neuroimaging measures in order to comprehensively assess the status of neuronal circuits in the pathophysiology of mood disorders. The applicant will also continue to devote time to mentoring junior investigators in POR especially as it relates to mood disorders in mid-late life. The applicant's scientific goals, objectives and career trajectory make the K24 mechanism optimal for his further growth and development in academic medicine.