LATE-LIFE DEPRESSION: NEUROBIOLOGICAL AND CLINICAL SUBSTRATES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 严重的抑郁症。研究神经解剖学变化和包括脑血管危险因素在内的整体医疗负担在初级保健/老年环境中出现的严重抑郁症的发展中所起的作用。我们研究的一个主要目的是将神经解剖学信息与临床和行为测量相结合，以便更全面地了解老年MDD的神经生物学基础。除了形态计量学之外，我们还建议将我们的磁共振方法扩展到包括质子磁共振波谱(MRS)，以检查重要的生化指标，如N-乙酰-L-天冬氨酸、胆碱、卵磷脂和肌醇(Mi)。总而言之，这些神经解剖学、生化和临床测量方法将提供对导致老年MDD抑郁的生物异常的更广泛的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MAJOR DEPRESSION. To examine the role of neuroanatomical changes and overall medical burden including cerebrovascular risk factors, in the development of major depression presenting at primary care/geriatric settings. A principal objective of our study is to integrate the neuroanatomical information with clincal and behavioral measures in order to obtain a more holistic picture of the neurobiologic basis of late-life MDD. In addition to morphometry, we propose to expand our MR approaches to include proton MR Spectroscopy (MRS), to examine revlevant biochemical measures such as N-Acetyl-L-Aspartate, Choline, Lecithin and myo-inosital (mI). Collectively these neuroanatomical, biochemical and clinical measures, will provide broader insights into the biological aberrations that lead to depression in late-life MDD.