PROTEIN MOLECULAR IMAGING IN PATIENTS WITH LATE-LIFE MAJOR DEPRESSION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项探索性研究的主要目的是使用正电子发射断层扫描（PET）与1，1-二氰基-2-[6-（二甲氨基）-2-萘基]丙烯（[18 F]FDDNP）的氟化类似物在患有晚期抑郁症（MDD）的患者和健康对照中检查蛋白质分子（淀粉样蛋白和tau蛋白）在大脑中的结合。另一个目标是检查[18F]FDDNP结合的关系，无论是全球和区域，以特定的认知措施（全球认知和执行功能和回忆的措施）。老年抑郁症既是痴呆症的危险因素，也是痴呆症的前驱症状，尤其是阿尔茨海默型痴呆症（AD）。FDDNP是一种有效的体内探针，其结合蛋白质，淀粉样蛋白和tau蛋白（分别是脑中神经炎斑块和神经纤维缠结的核心生化成分）。与对照组相比，诊断为AD和轻度认知障碍（MCI）的患者中FDDNP结合率更高，体内结合与神经病理学的尸检证据密切相关。我们的建议将帮助我们横断面检查MDD患者的总体蛋白质负荷及其与认知表现的关系。这个初步项目将导致纵向研究，检查FDDNP结合长期临床结果的关系，并比较MDD与诊断为可能AD的患者的结合模式。我们的观察将对老年人情绪和认知障碍的神经生物学产生重要影响。7.这项研究将有助于识别那些患有晚年抑郁症的患者，随着时间的推移，他们可能有患阿尔茨海默型痴呆症的风险。这将有助于早期识别可能受益于旨在缓解情绪和认知症状的积极治疗的患者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this exploratory study is to examine the binding of protein molecules, both amyloid and tau, in the brain using positron emission tomography (PET) with fluorinated analog of 1, 1-dicyano-2-[6- (dimethylamino)-2-naphthalenyl] propene ([18F]FDDNP) in patients with late life major depression (MDD) and healthy controls. An additional goal is to examine the relationship of [18F]FDDNP binding, both globally and regionally, to specific measures of cognition (global cognition and measures of executive function and recall). Depression in late-life is both a risk factor and a prodrome for dementia, especially dementia of the Alzheimer Type (AD). FDDNP is a valid in vivo probe that binds to protein, both amyloid and tau (core biochemical components of neuritic plaques and neurofibrillary tangles in the brain respectively). FDDNP binding is higher in patients diagnosed with AD and mild cognitive impairment (MCI) when compared with control subjects and in vivo binding correlates well with post mortem evidence of neuropathology. Our proposal will help us cross- sectionally examine overall protein burden and its relationship to cognitive performance in patients with MDD. This preliminary project will lead to longitudinal studies that examine the relationship of FDDNP binding to long term clinical outcome and a comparison of binding patterns in MDD to patients diagnosed with probable AD. Our observations will have important implications for the neurobiology of mood and cognitive disorders in the elderly. 7. Project Narrative The study will help identify patients with late-life depression who may be 'at risk' for developing dementia of the Alzheimer Type over time. This will facilitate the early identification of patients who may benefit from aggressive therapy aimed at alleviating both mood and cognitive symptoms.