PROTEIN MOLECULAR IMAGING IN PATIENTS WITH LATE-LIFE MAJOR DEPRESSION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项探索性研究的主要目的是用1，1-二氰基-2-[6-(二甲氨基)-2-萘基]丙烯([18F]FDDNP)的氟化类似物([18F]FDDNP)正电子发射断层扫描(PET)检测老年抑郁症(MDD)患者和健康对照组大脑中淀粉样蛋白和tau蛋白分子的结合情况。另一个目标是研究[18F]FDDNP的全球和区域约束力与具体认知指标(全球认知以及执行功能和回忆的指标)的关系。晚年抑郁既是痴呆的危险因素，也是痴呆的前兆，尤其是阿尔茨海默型痴呆(AD)。FDDNP是一种有效的体内探针，可以结合蛋白质，淀粉样蛋白和tau蛋白(分别是脑部神经炎斑块和神经原纤维缠结的核心生化成分)。在诊断为AD和轻度认知障碍(MCI)的患者中，FDDNP的结合比对照组高，体内结合与死后神经病理证据很好地相关。我们的建议将帮助我们横断面检查MDD患者的总体蛋白质负荷及其与认知表现的关系。这个初步项目将导致纵向研究，检查FDDNP结合与长期临床结果的关系，并比较MDD与可能诊断为AD的患者的结合模式。我们的观察将对老年人情绪和认知障碍的神经生物学产生重要影响。7.项目叙述这项研究将帮助确定老年抑郁症患者，随着时间的推移，他们可能有发展为阿尔茨海默型痴呆症的风险。这将有助于及早识别哪些患者可能受益于旨在缓解情绪和认知症状的积极治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this exploratory study is to examine the binding of protein molecules, both amyloid and tau, in the brain using positron emission tomography (PET) with fluorinated analog of 1, 1-dicyano-2-[6- (dimethylamino)-2-naphthalenyl] propene ([18F]FDDNP) in patients with late life major depression (MDD) and healthy controls. An additional goal is to examine the relationship of [18F]FDDNP binding, both globally and regionally, to specific measures of cognition (global cognition and measures of executive function and recall). Depression in late-life is both a risk factor and a prodrome for dementia, especially dementia of the Alzheimer Type (AD). FDDNP is a valid in vivo probe that binds to protein, both amyloid and tau (core biochemical components of neuritic plaques and neurofibrillary tangles in the brain respectively). FDDNP binding is higher in patients diagnosed with AD and mild cognitive impairment (MCI) when compared with control subjects and in vivo binding correlates well with post mortem evidence of neuropathology. Our proposal will help us cross- sectionally examine overall protein burden and its relationship to cognitive performance in patients with MDD. This preliminary project will lead to longitudinal studies that examine the relationship of FDDNP binding to long term clinical outcome and a comparison of binding patterns in MDD to patients diagnosed with probable AD. Our observations will have important implications for the neurobiology of mood and cognitive disorders in the elderly. 7. Project Narrative The study will help identify patients with late-life depression who may be 'at risk' for developing dementia of the Alzheimer Type over time. This will facilitate the early identification of patients who may benefit from aggressive therapy aimed at alleviating both mood and cognitive symptoms.