THE CEREBROVASCULAR BASIS OF DEPRESSION IN NON INSULIN DEPENDENT DIABETES MEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 探讨非胰岛素依赖型糖尿病(NIDDM，2型糖尿病)患者抑郁的脑血管基础。微血管疾病在抑郁症的病理生理学中的确切作用尚不清楚。微血管疾病和抑郁在NIDDM患者中共存，这使得它成为一种独特的临床模型，可以同时研究结构异常和微血管疾病在情绪障碍的病理生理中的作用。 具体目标1：为了研究NIDDM患者抑郁的神经解剖学相关性，我们建议使用磁共振成像(MRI)来获得脑体积和实质内高信号病变的体积估计。具体目的2：为了估计脑实质高信号病变和视网膜微血管病变的体积，将利用眼底照相来估计视网膜微血管疾病，视网膜微血管病变被概念化为脑内微血管疾病的标志。具体目标3：为了确定抑郁的危险因素以及从临床和神经解剖学基础到重度抑郁的途径，微血管测量将与神经解剖学指标相结合，以阐明NIDDM患者抑郁的病理生理过程和机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: To examine the cerebrovascular basis of depression in patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM, type 2 diabetes). The precise role of microvascular disease in the pathophysiology of depression is unknown. Microvascular disease and depression coexist in patients with NIDDM, rendering it a unique clinical model in which to concurrently examine the role of structural abnormalities and microvascular disease in the pathophysiology of mood disturbances. Specific Aim 1: To examine the neuroanatomical correlates of depression in patients with NIDDM, we propose to use magnetic resonance imaging (MRI) to obtain volumetric estimates of brain volume and the volume of high intensity lesions in the parenchyma. Specific Aim 2: To estimate the volume of high intensity lesions in the brain parenchyma and microvascular disease in the retina, fundus photography will be utilized to estimate microvascular disease in the retina and retinal microangiopathy is conceptualized as a marker of microvascular disease in the brain. Specific Aim 3: To identify risk factors for depression and pathways that lead from clinical and neuroanatomical substrates to major depression, microvascular measures will be integrated with neuroanatomic indices in order to elucidate the pathways and mechanisms involved in the pathophysiology of depression in patients with NIDDM.