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Midcareer Investigator Award

职业生涯中期研究员奖

基本信息

批准号：
7373572
负责人：
Clayton A. Wiley
金额：
$ 13.47万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-07-15 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7373572
关键词：
AIDS Dementia Complex AIDS-Related Disorder Abate Academic degree Academy Accounting Accreditation Acquired Immunodeficiency Syndrome Acute Address Adhesions Administrator Affect Age Aging Agriculture Alabama Algorithms Alzheimer&apos s Disease American Animal Experimentation Animal Model Animals Appearance Appendix Applications Grants Appointment Area Arts Astrocytosis Attention Autopsy Autoradiography Award Back Baltimore Basic Science Behavior Benzodiazepine Receptor Binding Biology Biomedical Research Biopsy Biotechnology Blood Blood - brain barrier anatomy Blood Cells Blood specimen Brain Brain Injuries Brain imaging Brain region CD14 gene CD4 Lymphocyte Count CD4 Positive T Lymphocytes CD80 gene California Carbon Cardiovascular system Caring Cataloging Catalogs Cell Communication Cell Count Cell Line Cell Nucleus Cells Central Nervous System Diseases Cerebrovascular Circulation Cerebrum Cessation of life Chairperson Characteristics Chicago Chronic Clinical Clinical Clerkship Clinical Investigator Clinical Markers Clinical Pathology Clinical Research Clinical Sciences Clinical Services Clinical Trials Cognition Cognitive Collaborations Colorado Commit Communities Competence Complement Complex Computer software Confocal Microscopy Contracts Control Groups Coroner Country County Cross-Sectional Studies DAA 1106 Data Data Analyses Dementia Democratic Republic of the Congo Depth Developing Countries Development Diagnosis Diffuse Diffuse Axonal Injury Direct Costs Disabled Persons Disadvantaged Disease Disease Progression Disease regression Doctor of Medicine Doctor of Philosophy Doctor of Veterinary Medicine Dose Drug abuse Edema Education Educational Curriculum Educational Status Educational process of instructing Educational workshop Elements Employment Encapsulated Encephalitis Encephalopathies Enrollment Environment Epidemic Equation Equilibrium Ethics Etiology Evaluation Event Evolution Exhibits Experimental Pathology Extracellular Matrix FCGR3B gene Facilities and Administrative Costs Faculty Feedback Fellowship Fellowship Program Financial compensation Florida Flow Cytometry Flowers Forensic Medicine Fostering Foundations Frequencies Functional Magnetic Resonance Imaging Funding Future Gadolinium Glass Glioma Globus Pallidus Goals Grant Guidelines HIV HIV Infections HIV associated minor cognitive dysfunction HIV encephalitis HIV-1 Head Health Sciences Herpes Simplex Infections Hippocampus (Brain)Histologic Hour Human Human Resources Human immunodeficiency virus test Image Imaging technology Immune Immunologic Monitoring Immunosuppression Impaired cognition Impairment In Vitro Incidence Individual Infarction Infection Infiltration Institutes Institution Instruction International International Agencies Internships Interview Investigation Japan Joints Jordan Journals K-Series Research Career Programs Kinetics Knowledge Label Laboratories Laboratory Research Lasers Learning Length Lesion Letters Life Ligand Binding Ligands Link Literature Location Logistic Regressions Logistics Los Angeles Lung Macaca Macaca mulatta Macrophage Activation Magnetic Resonance Imaging Manuals Manuscripts Maps Maryland Measurement Measures Mediating Mediator of activation protein Medical Medical Research Medical Students Medical center Medicine Mental disorders Mentored Clinical Scientist Development Program Mentors Mentorship Methods Microglia Microscope Microscopic Minnesota Minor Minority Mission Modality Modeling Monitor Monkeys Mononuclear Morbidity - disease rate Motivation Multiple Sclerosis NIH Center for Scientific Review Names National Institute of Mental Health Nebraska Neocortex Neostriatum Nerve Degeneration Nervous System Physiology Nervous System Trauma Nervous system structure Neurobiology Neurocognitive Neurodegenerative Disorders Neurologic Neurologic Symptoms Neurological observations Neurologist Neurology Neurons Neuropsychology Neurosciences Neurosciences Research Neurosciences, Other Neurosurgical Procedures Nevada New York Nigeria Numbers Ontario Ophthalmologist Opportunistic Infections Organ Orosomucoid Other Minority Outcome PK 11195 Pan Genus Paper Parietal Lobe Parkinson Disease Participant Pathogenesis Pathologic Pathologist Pathology Pathway interactions Patients Pediatric Hospitals Pennsylvania Peptides Perfusion Peripheral Peripheral Blood Mononuclear Cell Pharmaceutical Preparations Pharmacotherapy Phase Physicians Pilot Projects Placement Plasma Plasma Proteins Pontine structure Population Positioning Attribute Positron-Emission Tomography Postdoctoral Fellow Price Primates Principal Investigator Private Practice Prize Process Production Prophylactic treatment Proteins Protocols documentation Psychiatry Public Health Schools Publications Publishing Purpose Qualifying RNA Rabies Radioactivity Radiochemistry Radiolabeled Range Rate Reading Recombinant Proteins Recruitment Activity Refractory Relative (related person)Research Research Personnel Research Project Grants Research Training Residencies Resistance Resolution Resources Rest Risk Factors Rodent Role Rosa Rotation Running SIV SIV encephalitis Saints Sample Size Sampling Scanning Schedule Schools Science Scientist Sclerosis Score Secure Sensitivity and Specificity Serial C Series Serum Severities Side Simian Acquired Immunodeficiency Syndrome Site Sleep Disorders Societies Solid Source Specificity Speed Staging Staining method Stains Standards of Weights and Measures Statistical Models Statistically Significant Structure Students Study Subject Suggestion Sum Surveys Synapses System Systemic infection T-Lymphocyte TNFRSF5 gene Techniques Technology Telefacsimile Terminal Disease Terminally Ill Testing Thailand Therapeutic immunosuppression Time Tissue Sample Tissues Toxic effect Training Training Programs Transplantation Immunology Treatment Efficacy Tritium Underrepresented Minority United States United States Food and Drug Administration United States National Institutes of Health Universities Urticaria Variant Viral Viral Load result Viremia Virginia Virus Virus Diseases Vision Visit Visual Voting Water Week Wisconsin Woman Wood material Work World Health Organization Writing abstracting age related base brain tissue career cerebral atrophy college comparison group cost day density dentate gyrus design enantiomer experience extracellular follow-up foot gray matter human subject image registration impression improved in vivo innovation insight interest invariant chain lectures light scattering lymph nodes macrophage medical schools member migration minority trainee monocyte mortality motor deficit nervous system disorder neurobehavioral neurocognitive test neuroimaging neuropathology neurosurgery neurotoxic nonhuman primate novel patient oriented patient oriented research peer peripheral blood physical science post-doctoral training posters pre-clinical pre-doctoral preclinical study professor programs putamen radioligand radiotracer relating to nervous system research study response role model size skills success symposium teacher theories trafficking uptake volunteer

项目摘要

DESCRIPTION (provided by applicant): The current proposal is a competitive renewal of a previously funded K24. The Principal Investigator, Dr. Clayton Wiley, is a clinical and experimental Neuropathologist with extensive experience in research of neurological disease and in mentorship of physician scientists. Dr. Wiley's research has focused on neurodegenerative diseases with particular emphasis on how the AIDS virus mediates neurological damage. He is an active investigator in 2 funded centers studying the neurodegenerative disorders of Alzheimer's Disease and Parkinson's Disease, a non-funded Center for AIDS Research and is currently a funded Principal Investigator of grants focused on HIV mediated damage of the brain. In the initial 5 years of this K24, Dr. Wiley transitioned his predominantly tissue based studies into a more clinical orientation examining the use of state of the art imaging technology to monitor immune cell interactions with the nervous system using human and non-human primates. The final 5 years of proposed K24 funding will be directed at completing these studies and broadening the approach to other neurodegenerative disorders (e.g. Alzheimer's Disease). Dr. Wiley is also an active mentor for physician scientists at all stages of training and has been a leading innovator in development of training programs. During the first 5 years of K24 support Dr. Wiley co-directed 2 T32 training programs, served on the executive committees of K30 and K12 programs and re-built and directed the Pittsburgh MSTP, taking a moribund program and creating a model training system for budding clinical investigators. Renewal of the K24 proposal will protect Dr. Wiley's time from classroom, clinical and administrative responsibilities allowing him to focus his efforts on developing his clinical research program. In addition to advancing his clinical and preclinical studies, Dr. Wiley will engage in a rigorous clinical scientist training didactic curriculum and participate in national and international workshops on imaging, modeling and statistical analyses.

描述(由申请人提供)：目前的方案是对以前资助的K24进行竞争性续签。首席研究员Clayton Wiley博士是一位临床和实验神经病理学家，在神经疾病研究和内科科学家的指导下拥有丰富的经验。威利博士的研究重点是神经退行性疾病，特别强调艾滋病病毒如何介导神经损伤。他是两个研究阿尔茨海默病和帕金森氏病神经退行性疾病的资助中心的活跃研究员，这是一个非资助的艾滋病研究中心，目前是专注于艾滋病毒介导的脑损伤的赠款的首席研究员。在K24的最初5年里，Wiley博士将他的主要基于组织的研究过渡到更临床的方向，检查使用最先进的成像技术来监测免疫细胞与神经系统的相互作用，使用人类和非人类灵长类动物。拟议的K24资金的最后5年将用于完成这些研究，并拓宽其他神经退行性疾病(例如阿尔茨海默病)的方法。威利博士也是内科科学家在所有培训阶段的积极导师，并在培训计划的发展方面一直是领先的创新者。在K24支持的头5年里，Wiley博士共同指导了2个T32培训计划，在K30和K12计划的执行委员会任职，并重新建立和指导了匹兹堡MSTP，接受了一个垂死挣扎的计划，并为初出茅庐的临床研究人员创建了一个模式培训系统。K24提案的续签将使Wiley博士的时间从课堂、临床和管理责任中解脱出来，使他能够集中精力开发他的临床研究计划。除了推进他的临床和临床前研究，Wiley博士还将参加严格的临床科学家培训教学课程，并参加关于成像、建模和统计分析的国内和国际研讨会。