Concurrent fMRI and NIRS of Frontal Lobe Activation During Marijuana Smoking

吸食大麻期间额叶激活的并行 fMRI 和 NIRS

• 批准号: 7500664
• 负责人: Blaise deBonneval Frederick
• 金额: $ 17.93万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7500664
• 关键词: Acute; Address; Affect; Air; Area; Back; Behavior; Behavior assessment; Behavioral; Blood; Blood flow; Brain; Brain imaging; Brain region; Child; Chronic; Companions; Compatible; Condition; Confined Spaces; Coupled; Data; Depth; Development; Devices; Drug effect disorder; Electroencephalography; Forehead; Functional Magnetic Resonance Imaging; Hair; Head; Hemoglobin; Hour; Illicit Drugs; Image; Imaging Techniques; Immune; Individual; Intoxication; Invasive; Knowledge; Literature; Localized; Location; Magnetic Resonance Imaging; Magnetism; Marijuana; Marijuana Dependence; Marijuana Smoking; Measurement; Measures; Methods; Modality; Moods; Morphologic artifacts; Motion; Nasal cavity; Near-Infrared Spectroscopy; Noise; Pattern; Perception; Performance; Pharmaceutical Preparations; Physiological; Population; Positron-Emission Tomography; Predisposition; Pregnant Women; Procedures; Process; Property; Relative (related person); Reporting; Resolution; Rewards; Scanning; Self Administration; Signal Transduction; Smoke; Smoking; Source; Surface; Techniques; Testing; Tissues; Vulnerable Populations; behavior measurement; blood oxygen level dependent; cost; craving; detector; experience; frontal lobe; image processing; imaging probe; infrared spectroscopy; magnetic field; novel; relating to nervous system; response; sensor; single photon emission computed tomography; tool

DESCRIPTION (provided by applicant): This R21 application proposes to develop a novel way of measuring brain function after smoking marijuana that combines Functional Magnetic Resonance Imaging (fMRI) and Near Infrared Spectroscopy (NIRS). Background: Marijuana remains the most commonly used illicit drug in the U.S., but we do not to date understand the full spectrum of its reinforcing effects. Advanced brain imaging techniques such as PET, SPECT, EEG and MRI have been used to explore the acute and chronic effects of marijuana, but each of these techniques has limitations that preclude its use in some situations or populations. Recently, we have developed a device that allows individuals to smoke marijuana during functional magnetic resonance imaging (fMRI) and have successfully correlated fMRI data with subjective reports of behavioral states such as high, and physiological responses. The merger of fMRI with behavior during smoking is an important breakthrough in our knowledge of the spatial and temporal patterns of brain activity changes during marijuana use. This knowledge will be crucial for the development of rational and effective treatments for marijuana dependence. Significance: However, there are three important issues that need to be addressed to maximize the utility of fMRI.. First, perception of pleasurable drug effects is subjective, and is modulated by mood. Subjects must remain immobile in a confined space for up to two hours and these conditions can be unnatural for some people, and most likely affect their perception of what would otherwise be a rewarding experience. Second, BOLD fMRI only gives information about deoxy-hemoglobin changes, not changes in oxy-hemoglobin or blood flow. Third, a major confound in brain fMRI is distortion and signal loss around regions of discontinuous magnetic susceptibility, specifically air-tissue interfaces. Also, there is considerable motion artifact. NIRS offers an ideal companion method for studying frontal brain activity changes that addresses all of these concerns. NIRS is a method for making local measurements of cortical blood oxygenation and flow, which are closely coupled to neural activity. While its spatial resolution is lower than fMRI, and it is limited to regions near the cortical surface, its temporal resolution is significantly better than fMRI. These qualities make it well suited to enhancing the data acquired with fMRI. Specific Aims: In this proposal, we will: 1) develop and optimize an fMRI compatible depth sensitive NIRS imaging probe for the study of frontal areas; 2) Compare frontal activations measured concurrently during marijuana smoking using NIRS and BOLD fMRI, and 3) compare NIRS activation in response to marijuana smoking inside the fMRI scanner to activation in a natural setting. This study will pave the way for using brain imaging in vulnerable populations like children and pregnant women. This project aims to develop and validate an extremely safe, low-cost, non-invasive method for measuring the brain changes that occur during marijuana smoking. This study will pave the way for using brain imaging in vulnerable populations like children and pregnant women, and will provide a better understanding of the reinforcing effects of this drug. This understanding is a necessary step in developing strategies and therapies for reducing marijuana use and abuse.

描述（由申请人提供）：该R21申请提出开发一种测量吸食大麻后大脑功能的新方法，该方法结合了功能性磁共振成像（fMRI）和近红外光谱（NIRS）。背景：大麻仍然是美国最常用的非法药物，但我们至今还不了解其强化作用的全部范围。先进的脑成像技术，如PET，SPECT，EEG和MRI已被用于探索大麻的急性和慢性影响，但这些技术中的每一种都有局限性，无法在某些情况或人群中使用。最近，我们开发了一种设备，允许个人在功能性磁共振成像（fMRI）过程中吸食大麻，并成功地将fMRI数据与行为状态（如高）和生理反应的主观报告相关联。功能磁共振成像与吸烟行为的结合是我们对大麻使用期间大脑活动变化的空间和时间模式的认识的重要突破。这些知识对于开发合理有效的大麻依赖治疗方法至关重要。意义：然而，有三个重要的问题需要解决，以最大限度地发挥功能磁共振成像的效用。首先，对药物愉悦效果的感知是主观的，并受到情绪的调节。受试者必须在密闭空间中保持长达两个小时的不动，这些条件对某些人来说可能是不自然的，并且很可能影响他们对本应是有益体验的感知。第二，BOLD功能磁共振成像只给出了脱氧血红蛋白变化的信息，而不是氧合血红蛋白或血流的变化。第三，大脑功能磁共振成像的一个主要混淆是不连续磁化率区域周围的失真和信号丢失，特别是空气-组织界面。此外，存在相当大的运动伪影。NIRS为研究额叶脑活动变化提供了一种理想的伴侣方法，可以解决所有这些问题。近红外光谱是一种用于局部测量皮质血氧和血流的方法，其与神经活动密切相关。虽然它的空间分辨率低于fMRI，并且仅限于皮层表面附近的区域，但其时间分辨率明显优于fMRI。这些特性使其非常适合增强功能磁共振成像获得的数据。具体目标：在本提案中，我们将：1）开发和优化fMRI兼容的深度敏感NIRS成像探头，用于额叶区域的研究; 2）比较使用NIRS和BOLD fMRI在吸食大麻期间同时测量的额叶激活; 3）比较在fMRI扫描仪内响应于吸食大麻的NIRS激活与在自然环境中的激活。这项研究将为在儿童和孕妇等弱势群体中使用脑成像铺平道路。该项目旨在开发和验证一种非常安全，低成本，非侵入性的方法来测量吸食大麻期间发生的大脑变化。这项研究将为在儿童和孕妇等弱势群体中使用脑成像铺平道路，并将更好地了解这种药物的强化作用。这种理解是制定减少大麻使用和滥用的策略和疗法的必要步骤。

项目成果

Physiological denoising of BOLD fMRI data using Regressor Interpolation at Progressive Time Delays (RIPTiDe) processing of concurrent fMRI and near-infrared spectroscopy (NIRS).

在渐进式延迟（Riptide）处理并发fMRI和近红外光谱（NIRS）时，使用回归插值（RIPTIDE）处理时使用回归插值来对BOLD FMRI数据进行生理降解。

• DOI: 10.1016/j.neuroimage.2012.01.140
• 发表时间: 2012-04-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Frederick, Blaise deB.;Nickerson, Lisa D.;Tong, Yunjie
• 通讯作者: Tong, Yunjie

An improved method for mapping cerebrovascular reserve using concurrent fMRI and near-infrared spectroscopy with Regressor Interpolation at Progressive Time Delays (RIPTiDe).

• DOI: 10.1016/j.neuroimage.2011.03.071
• 发表时间: 2011-06-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Tong, Yunjie;Bergethon, Peter R.;Frederick, Blaise deB
• 通讯作者: Frederick, Blaise deB

Time lag dependent multimodal processing of concurrent fMRI and near-infrared spectroscopy (NIRS) data suggests a global circulatory origin for low-frequency oscillation signals in human brain.

• DOI: 10.1016/j.neuroimage.2010.06.049
• 发表时间: 2010-11-01
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Tong, Yunjie;Frederick, Blaise deB.
• 通讯作者: Frederick, Blaise deB.

Perturbation theory for the diffusion equation by use of the moments of the generalized temporal point-spread function. III. Frequency-domain and time-domain results.

使用广义时间点扩散函数的矩的扩散方程的微扰理论。

• DOI: 10.1364/josaa.27.001723
• 发表时间: 2010
• 期刊: Journal of the Optical Society of America. A, Optics, image science, and vision
• 作者: Sassaroli,Angelo;Martelli,Fabrizio;Fantini,Sergio
• 通讯作者: Fantini,Sergio