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Realtime Near Infrared Spectroscopy of the Frontal Lobe for Neurofeedback

用于神经反馈的额叶实时近红外光谱

基本信息

批准号：
8139953
负责人：
Blaise deBonneval Frederick
金额：
$ 22.76万
依托单位：
MCLEAN HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-15 至 2014-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8139953
关键词：
AODD relapse Affect Area Attention Behavior Behavioral Bilateral Biofeedback Blood Pressure Blood flow Brain Brain imaging Brain region Computer software Conscious Cues Data Data Display Decision Making Drug Addiction Educational process of instructing Electroencephalography Emotional Feedback Functional Imaging Functional Magnetic Resonance Imaging Functional disorder Goals Heart Rate Helmet Hemoglobin Image Individual Inferior Learning Linear Models Measurement Measures Methodology Methods Modeling Monitor Morphologic artifacts Motion Near-Infrared Spectroscopy Noise Optics Outcome Pain Perception Performance Pharmaceutical Preparations Physiological Population Positron-Emission Tomography Prefrontal Cortex Probability Procedures Process Psyche structure Quality Control Relapse Research Resolution Risk Scanning Self-control as a personality trait Signal Transduction Smoker Sorting - Cell Movement Specific qualifier value Stimulus Stress System Testing Time Tobacco Training Visual Work addiction analog base behavior measurement combat cost craving data acquisition design drug craving drug seeking behavior frontal lobe hemodynamics human subject improved mind control neurofeedback non-smoker novel public health relevance relating to nervous system response spectroscopic imaging substance abuse prevention tool treatment strategy

项目摘要

DESCRIPTION (provided by applicant): This R21 proposal will develop and validate a real-time near infrared spectroscopy (NIRS) imaging system that will allow subjects to monitor their own frontal brain activity, as it happens, in order to learn to modulate this activity. By modulating activity in frontal regions associated with drug craving and drug seeking behavior, subjects may be able to learn strategies to reduce drug craving a reduce the probability of relapse. Background: Biofeedback teaches individuals how to regulate autonomic bodily functions normally considered to be outside of the realm of conscious control by giving them immediate and continuous feedback reflecting the state of a process that is normally not perceptible to them. Neurofeedback is an extension of this concept where the quantity presented to the subject represents a measure of neural activity in a target brain region. Neurofeedback using EEG and real-time fMRI has shown utility in increasing attention, enhancing musicality, and improving mod, and modifying the subjective perception of pain. Real-time NIRS (rtNIRS) offers a potential alternative method for high-quality measurement of frontal cortical brain activity, an area important in decision-making processes having to do with drug craving and seeking, with good spatial localization, high temporal resolution, and simple acquisition hardware that is relatively portable and low-cost. Conscious control of brain activity in this region could blunt the drug craving that leads to relapse. Significance: Neurofeedback with rtNIRS has the potential to become a powerful tool for treatment of substance abuse and prevention of relapse. Real-time neurofeedback with rtfMRI has been shown to be effective in modulating a wide range of behaviors and perceptions. rtNIRS could potentially offer the benefits of neurofeedback at much lower cost and in a wider range of populations than rtfMRI. Specific Aims: 1) Develop an optical helmet optimized for real-time frontal lobe neurofeedback. The target design will provide good bilateral coverage of areas, and provide measurements of extracerebral blood flow to allow these signals to be modeled and removed during analysis; 2) Implement a real-time NIRS processing chain. This aim will streamline the data recording and analysis process of our current NIRS system so that NIRS data will be preprocessed and analyzed for presentation to the subject with less than 1 second latency; 3) Implement a feedback system to present brain activity data to the subject. In this aim we will evaluate candidate visual representations of neural activity for their ability to assist subject training 4) Investigate the feasibility of conscious control of brain activity in a specified frontal brain region with feedback consisting of real-time measures of regional activation. Frontal cortical executive whether neurofeedback alters performance on Go-NoGo and Balloon Analog Risk Tasks. Realtime NIRS will We will test provide a complementary methodology to real-time fMRI and EEG for modulating brain activity, as a step towards the goal of developing a novel treatment strategy to combat substance abuse and relapse. PUBLIC HEALTH RELEVANCE: The goal of this project is to develop and test a real-time near infrared spectroscopic (NIRS) functional imaging system to allow subjects to directly monitor, and as a result modulate, their frontal brain activity. The data from this exploratory study will be used to develop a novel and potentially important tool for training subjects to reduce drug craving and drug seeking behaviors.

描述（由申请人提供）：该R21提案将开发和验证一种实时近红外光谱（NIRS）成像系统，该系统将允许受试者监测他们自己的额叶脑活动，以便学习调节这种活动。通过调节与药物渴望和药物寻求行为相关的额叶区域的活动，受试者可能能够学习减少药物渴望的策略，从而降低复发的概率。背景资料：生物反馈教导个体如何调节通常被认为是意识控制领域之外的自主身体功能，通过给他们即时和连续的反馈，反映他们通常无法感知的过程状态。神经反馈是这一概念的延伸，其中呈现给受试者的量表示目标大脑区域中神经活动的测量。使用EEG和实时fMRI的神经反馈在增加注意力、增强音乐性、改善MOD和修改疼痛的主观感知方面显示出实用性。实时近红外光谱（rtNIRS）提供了一种潜在的替代方法，用于高质量的测量额叶皮层的大脑活动，一个重要的区域在决策过程中与药物渴求和寻求，具有良好的空间定位，高时间分辨率，和简单的采集硬件，是相对便携和低成本。有意识地控制这个区域的大脑活动可以减弱导致复发的药物渴望。意义：神经反馈与rtNIRS有可能成为治疗药物滥用和预防复发的有力工具。 rtfMRI的实时神经反馈已被证明在调节广泛的行为和感知方面有效。与rtfMRI相比，rtNIRS可能以更低的成本和更广泛的人群提供神经反馈的好处。具体目标：1）开发一种针对实时额叶神经反馈优化的光学头盔。目标设计将提供良好的双侧区域覆盖，并提供脑外血流的测量，以允许在分析期间对这些信号进行建模和去除; 2）实现实时NIRS处理链。这一目标将简化我们目前的NIRS系统的数据记录和分析过程，使NIRS数据将被预处理和分析，以小于1秒的延迟呈现给受试者; 3）实现反馈系统，以向受试者呈现大脑活动数据。在这个目标中，我们将评估候选的视觉表征的神经活动，他们的能力，以协助受试者的培训4）调查的可行性，有意识地控制大脑活动在一个特定的额叶脑区的反馈组成的实时测量区域激活。额叶皮层执行神经反馈是否会改变Go-NoGo和气球模拟风险任务的表现。我们将测试提供一种补充方法，实时功能磁共振成像和脑电图调制大脑活动，作为一个步骤，朝着发展一种新的治疗策略，以打击药物滥用和复发的目标。公共卫生关系：该项目的目标是开发和测试一种实时近红外光谱（NIRS）功能成像系统，使受试者能够直接监测，并因此调节他们的额叶脑活动。这项探索性研究的数据将用于开发一种新的和潜在的重要工具，用于训练受试者减少药物渴望和药物寻求行为。