ROLES OF INFLAMMATION AND ANDROGEN METABOLISM IN PROSTATE CANCER DISPARITY

炎症和雄激素代谢在前列腺癌差异中的作用

• 批准号: 7305658
• 负责人: RICARDO RICHARDSON
• 金额: $ 13.88万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7305658
• 关键词: African American; Androgen Metabolism; Androgens; Apoptotic; Arachidonate 5-Lipoxygenase; Arachidonic Acids; Arrestin; Arrestins; Biopsy Specimen; Blood; Caucasians; Caucasoid Race; Clinical; Cultured Cells; Data; Development; Enzymes; Epidermal Growth Factor; Epidermal Growth Factor Receptor; Excretory function; Family; Frequencies; Gene Expression Regulation; Genes; Genetic Polymorphism; Genotype; Glucuronosyltransferase; Grant; IL8 gene; IL8RA gene; IL8RB gene; Individual; Inflammation; Inflammatory; Interleukin 8A Receptor; Interleukin-8; Knock-out; LTB4R gene; Laboratories; Leukotriene B4; Lewis Lung Carcinoma; Link; Malignant neoplasm of prostate; Mediating; Mediator of activation protein; Metabolism; Methylation; Modeling; Molecular; Mus; Neoplasm Metastasis; Outcome; PC3 cell line; Pathway interactions; Pattern; Play; Population; Production; Prostate; Prostatic Neoplasms; Prostatic Tissue; Protein Overexpression; Receptor Signaling; Regulation; Relative (related person); Role; Sampling; Small Interfering RNA; Testing; Testosterone; Tissue Sample; Tissues; Tumor Angiogenesis; UGT2B28 UDP-glucuronosyltransferase; angiogenesis; cancer cell; cancer health disparity; cancer risk; case control; chemokine; chemokine receptor; in vivo; leucylarginine; men; mouse model; novel; promoter; protein expression; receptor; receptor expression; tumor; tumorigenesis

African Americans are >60% more likely to develop and >200% more likely to die from prostate cancer than their Caucasian counterparts. It is known that African Americans are more likely to have inflammation in their prostate biopsy specimens, and tend to have higher levels of androgens in blood than Caucasians. Therefore, we hypothesize that inflammation and androgens metabolism may play critical roles in prostate cancer disparity. We plan to test our hypotheses with the following three Specific Aims: 1) To study whether p-arrestin may contribute to prostate cancer disparity by modulating CXCR2-mediated angiogenesis and metastasis of prostate cancer (PI: Richardson). 2) To determine whether expression and regulation of AloxS and bltl by promoter methylation and polymorphism may contribute to prostate cancer disparity between African American and Caucasian men (PI: Chen). 3) To determine whether polymorphisms of UGT2B genes may contribute to prostate cancer development and disparity (PI: Grant). This project is a multi-Pi and multi-disciplinary study which incorporates expertise of three laboratories to study molecular mechanism of prostate cancer disparity. We expect to define the roles of inflammation and androgen metabolism in prostate cancer disparity.

非裔美国人患前列腺癌的可能性要高出60%死于前列腺癌的可能性要高出200%