ROLES OF INFLAMMATION AND ANDROGEN METABOLISM IN PROSTATE CANCER DISPARITY

非裔美国人患前列腺癌的可能性比非裔美国人高60%，死于前列腺癌的可能性比非裔美国人高200%。 他们的高加索同行。据了解，非洲裔美国人更有可能在他们的炎症。 前列腺活检标本，并往往有较高水平的雄激素在血液中比高加索人。 因此，我们假设炎症和雄激素代谢可能在前列腺疾病中起关键作用。 癌症差异 我们计划通过以下三个具体目标来检验我们的假设： 1)研究p-抑制蛋白是否可能通过调节CXCR 2介导的前列腺癌细胞凋亡而导致前列腺癌差异。 前列腺癌的血管生成和转移（PI：Richardson）。 2)为了确定AloxS和bltl的表达和调控是否通过启动子甲基化和 多态性可能导致非裔美国人和白人男性之间前列腺癌的差异 (PI：Chen）。 3)确定UGT 2B基因多态性是否可能导致前列腺癌的发生 和差距（PI：格兰特）。 该项目是一项多学科和多学科的研究，结合了三个实验室的专业知识， 研究前列腺癌差异分子机制。我们希望能明确炎症的作用， 前列腺癌的雄激素代谢差异。

African Americans are >60% more likely to develop and >200% more likely to die from prostate cancer than their Caucasian counterparts. It is known that African Americans are more likely to have inflammation in their prostate biopsy specimens, and tend to have higher levels of androgens in blood than Caucasians. Therefore, we hypothesize that inflammation and androgens metabolism may play critical roles in prostate cancer disparity. We plan to test our hypotheses with the following three Specific Aims: 1) To study whether p-arrestin may contribute to prostate cancer disparity by modulating CXCR2-mediated angiogenesis and metastasis of prostate cancer (PI: Richardson). 2) To determine whether expression and regulation of AloxS and bltl by promoter methylation and polymorphism may contribute to prostate cancer disparity between African American and Caucasian men (PI: Chen). 3) To determine whether polymorphisms of UGT2B genes may contribute to prostate cancer development and disparity (PI: Grant). This project is a multi-Pi and multi-disciplinary study which incorporates expertise of three laboratories to study molecular mechanism of prostate cancer disparity. We expect to define the roles of inflammation and androgen metabolism in prostate cancer disparity.