IMMUNOGENETIC DISEASES: CONTROL SUBJECTS

免疫性疾病：对照受试者

• 批准号: 7609595
• 负责人: ELIZABETH K. TAM
• 金额: $ 1.57万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609595
• 关键词: Address; Affect; Area; Asthma; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Development; Early Intervention; Extrinsic asthma; Funding; Grant; Hawaii; Immunogenetics; Inflammation; Institution; Lupus; Population; Predisposition; Process; Research; Research Personnel; Resources; Rheumatic Fever; Rheumatic Heart Disease; Severities; Signal Transduction; Source; Time; United States National Institutes of Health; Variant; Work; airway remodeling; disorder control

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "Immunogenetic Diseases: Control Subjects" was developed to support the three developmental projects in the RCMI Immunogenetics Activity examining the susceptibility and severity of asthma, lupus or rheumatic fever in Hawaii's population. The aims of the control group are to charaterize subjects who are not affected by asthma, lupus, rheumatic fever/rheumatic heart disease. The proposed work addresses two relatively unexplored areas. First, it examines whether genetc variants described in other populations similarly contribute to allergic asthma in Hawaii's unique ethnic blend. Secondly, this work focuses on that part of the asthma continuum in which early inflammation signals regulate the onset, progression of termination of fibrotic processes. If the contribution of specific signals can be delineated, early interventions may be targeted and/or more time may be gained to stop later complications of asthma, such as airway remodeling.

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