IMMUNOGENETIC DISEASES: CONTROL SUBJECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 “免疫遗传疾病：对照受试者”是为了支持RCMI免疫遗传活动中的三个开发项目而开发的，该活动检测夏威夷人口中哮喘、狼疮或风湿热的易感性和严重程度。对照组的目的是确定不受哮喘、狼疮、风湿热/风湿性心脏病影响的受试者的特征。拟议的工作涉及两个相对未开发的领域。首先，它检查了在其他人群中描述的基因ETC变体是否类似地在夏威夷独特的种族混合中导致过敏性哮喘。其次，这项工作集中在哮喘连续体中早期炎症信号调节纤维化过程的开始和发展的那部分。如果能够描述特定信号的作用，可以有针对性地进行早期干预，和/或获得更多的时间来阻止哮喘后期的并发症，如气道重塑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "Immunogenetic Diseases: Control Subjects" was developed to support the three developmental projects in the RCMI Immunogenetics Activity examining the susceptibility and severity of asthma, lupus or rheumatic fever in Hawaii's population. The aims of the control group are to charaterize subjects who are not affected by asthma, lupus, rheumatic fever/rheumatic heart disease. The proposed work addresses two relatively unexplored areas. First, it examines whether genetc variants described in other populations similarly contribute to allergic asthma in Hawaii's unique ethnic blend. Secondly, this work focuses on that part of the asthma continuum in which early inflammation signals regulate the onset, progression of termination of fibrotic processes. If the contribution of specific signals can be delineated, early interventions may be targeted and/or more time may be gained to stop later complications of asthma, such as airway remodeling.