IMMUNOGENETIC DISEASES: CONTROL SUBJECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 免疫遗传疾病：“对照受试者”的开发是为了支持RCMI免疫遗传学活动中的三个发展项目，这些项目检查了夏威夷人口中哮喘、狼疮或风湿热的易感性和严重程度。 对照组的目的是表征未受哮喘、狼疮、风湿热/风湿性心脏病影响的受试者。 拟议的工作涉及两个相对未探索的领域。首先，它检查了在其他人群中描述的基因变异是否同样有助于夏威夷独特的种族混合过敏性哮喘。 其次，这项工作的重点是哮喘连续体的一部分，其中早期炎症信号调节纤维化过程的开始，进展和终止。 如果可以描绘特定信号的贡献，则可以针对早期干预和/或可以获得更多的时间来阻止哮喘的后期并发症，例如气道重塑。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "Immunogenetic Diseases: Control Subjects" was developed to support the three developmental projects in the RCMI Immunogenetics Activity examining the susceptibility and severity of asthma, lupus or rheumatic fever in Hawaii's population. The aims of the control group are to charaterize subjects who are not affected by asthma, lupus, rheumatic fever/rheumatic heart disease. The proposed work addresses two relatively unexplored areas. First, it examines whether genetc variants described in other populations similarly contribute to allergic asthma in Hawaii's unique ethnic blend. Secondly, this work focuses on that part of the asthma continuum in which early inflammation signals regulate the onset, progression of termination of fibrotic processes. If the contribution of specific signals can be delineated, early interventions may be targeted and/or more time may be gained to stop later complications of asthma, such as airway remodeling.