IMMUNOGENETIC DISEASES: CONTROL SUBJECTS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "Immunogenetic Diseases: Control Subjects" was developed to support the three developmental projects in the RCMI Immunogenetics Activity examining the susceptibility and severity of asthma, lupus or rheumatic fever in Hawaii's population. The aims of the control group are to charaterize subjects who are not affected by asthma, lupus, rheumatic fever/rheumatic heart disease. The proposed work addresses two relatively unexplored areas. First, it examines whether genetc variants described in other populations similarly contribute to allergic asthma in Hawaii's unique ethnic blend. Secondly, this work focuses on that part of the asthma continuum in which early inflammation signals regulate the onset, progression of termination of fibrotic processes. If the contribution of specific signals can be delineated, early interventions may be targeted and/or more time may be gained to stop later complications of asthma, such as airway remodeling.