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Synaptic connections and electrophysiological properties of neurones in the intermedius nucleus of the medulla oblongata

延髓中间核神经元的突触连接和电生理特性

基本信息

批准号：
BB/F006594/1
负责人：
Jim Deuchars
金额：
$ 46.29万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FF006594%2F1
关键词：
Synaptic connections electrophysiological properties neurones

项目摘要

Experiments in our laboratory have brought to our attention a collection of nerve cells (neurones) whose function is unknown. The neurones are located in a discrete region in the brainstem, the part of the brain that controls body systems critical for breathing and cardiovascular maintenance. The nucleus in which the neurones reside is known to receive information from neck muscles when they are stretched, but what this information is used for needs to be determined. Our preliminary evidence supports at least two ideas for cells in this nucleus / signalling neck muscle stretching to circuits involved in cardiorespiratory control and/or those involved in co-ordinating swallowing and breathing. To help determine if the cells participate in controlling such functions, we will investigate what other brain regions they send information to and receive information from using contemporary neuroanatomical methods. This will involve identifying cell types in the other brain regions where possible. We will also closely investigate the anatomical and electrical properties of the cells themselves since these features infleunce how the cells respond to incoming information and therefore how this information is passed on to other neurones. These studies will therefore clarify the connections and functions of an unexplored brain nucleus that we propose is involved in controlling important body functions.

我们实验室的实验使我们注意到一组功能未知的神经细胞（神经元）。神经元位于脑干的一个离散区域，脑干是大脑的一部分，控制着对呼吸和心血管维持至关重要的身体系统。神经元所在的神经核在颈部肌肉被拉伸时会接收来自颈部肌肉的信息，但这些信息的用途还有待确定。我们的初步证据支持至少两个想法，即这个核/信号颈部肌肉中的细胞伸展到参与心肺控制和/或参与协调吞咽和呼吸的电路。为了帮助确定这些细胞是否参与控制这些功能，我们将使用当代神经解剖学方法研究它们向哪些其他大脑区域发送信息和从哪些区域接收信息。这将涉及在可能的情况下识别其他大脑区域中的细胞类型。我们还将仔细研究细胞本身的解剖学和电学特性，因为这些特征影响细胞如何对传入信息作出反应，从而影响这些信息如何传递给其他神经元。因此，这些研究将阐明一个未被探索的脑核的连接和功能，我们认为它参与控制重要的身体功能。