Building Sustainable Research Capacity at Mansoura Egypt

埃及曼苏拉可持续研究能力建设

基本信息

批准号：
7392260
负责人：
Vishwajit Laxmikant Nimgaonkar
金额：
$ 11.8万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7392260
关键词：
Adolescence Affect Age Applications Grants Attention Award Bipolar Disorder Blood specimen Brain Diseases Caucasians Caucasoid Race Childhood Clinical Clinical Research Collaborations Communities Complex Consanguinity Consultations Control Groups Controlled Study DEFB1 gene DNA Markers Data Data Analyses Developed Countries Developing Countries Development Diagnosis Diagnostic Diagnostic Procedure Diagnostic and Statistical Manual Disease Educational process of instructing Educational workshop Egypt Environmental Risk Factor Epidemiology Equipment Ethnic group Faculty Family history of First Degree Relative Funding Future Gender Genetic Genetic Research Genetic Techniques Genome Goals Grant Hand Hospitals Inbreeding India Individual Inheritance Patterns International Interview Investigation Knowledge Learning Maps Medicine Middle East Molecular Genetics Parents Participant Patients Persons Prevalence Prospective Studies Psychiatrist Psychiatry Psychotic Disorders Rate Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Sampling Schedule Schizoaffective Disorders Schizophrenia Site Socioeconomic Status Source Supervision Susceptibility Gene Techniques Training Universities University Hospitals Work base data management design experience genetic analysis insight international center member neglect proband psychogenetics research clinical testing

项目摘要

DESCRIPTION (provided by applicant): The aim of this application is threefold: (1) to build research infrastructure in Mansoura, Egypt through collaboration with Mansoura University Hospital; (2) to conduct a focused research project investigating the hypothesis that there is increased consanguinity among parents of patients with schizophrenia as compared to parents of unaffected controls; and (3) to collect data that will enable a future R01 grant. This project will enable training for three Egyptian psychiatrists in clinical evaluation techniques through workshops and teaching at the University of Pittsburgh and Mansoura University Hospital. One other individual will be trained in basic molecular genetic techniques, and relevant equipment will be purchased in order to initiate genetic molecular research at Mansoura University Hospital. All the trainees will learn data management and data analysis techniques. Trainees will experience hands-on learning through participation in a focused research project investigating the rate of parental consanguinity among Egyptian patients diagnosed with schizophrenia (n=100) compared with a group of controls (n=100) who have a similar distribution of socio-economic status, age and gender as the patients. Preliminary studies have suggested higher rates of parental consanguinity among patients with schizophrenia than among controls, and this study will further investigate this hypothesis. Controls (n=100) and parents of controls (n=200) are already being recruited through a previously funded FIRCA study. Patients with schizophrenia (n=100) and their parents (n=200) will be ascertained by the Egyptian trainees. Schizophrenia is a common, lifelong, disabling illness which receives relatively little attention in developing countries. Research into the epidemiology of schizophrenia in Egypt is sparse and testifies to the neglected state of this field. Ongoing efforts to map susceptibility genes for schizophrenia have suggested complex interactions between several genetic and environmental factors. Most such studies have been conducted among Caucasians. Complementary investigations of other ethnic groups may yield useful insights, especially if unusual patterns of inheritance are observed.

描述（由申请人提供）：本申请的目的是三倍：（1）通过与曼苏拉大学医院的合作在埃及曼苏拉建立研究基础设施；（2）进行一个集中的研究项目，该项目调查了一个假设，即与未受影响的对照的父母相比，精神分裂症患者父母的血缘关系增加；（3）收集将获得未来R01赠款的数据。该项目将通过研讨会和匹兹堡大学和曼苏拉大学医院的讲习班和教学，以促进三名埃及精神科医生的培训。另一个人将接受基本分子遗传技术的培训，并将购买相关的设备，以便在曼苏拉大学医院开始遗传分子研究。所有受训人员将学习数据管理和数据分析技术。与一组对照组（n = 100）相比，学员将通过参与一项重点研究项目（埃及诊断为精神分裂症（n = 100））的父母血缘关系的速度（n = 100），他们将通过参与一个重点研究项目（n = 100）来体验动手学习。初步研究表明，精神分裂症患者的父母血缘率要高于对照组，这项研究将进一步研究这一假设。对照（n = 100）和对照组的父母（n = 200）已经通过先前资助的FIRCA研究招募。精神分裂症患者（n = 100）及其父母（n = 200）将由埃及学员确定。精神分裂症是一种常见的，终生残疾的疾病，在发展中国家受到相对较少的关注。埃及精神分裂症流行病学的研究很少，并证明了该领域的被忽视状态。持续绘制精神分裂症易感基因的努力表明，几种遗传和环境因素之间的相互作用复杂。大多数此类研究都是在高加索人中进行的。对其他种族的互补研究可能会产生有用的见解，尤其是在观察到异常的继承模式时。