ISLET COMPLEX LIPID IN GROUP VIA CALCIUM INDEPENDENT PHOSPHOLIPASE A2 IN B CELL

B 细胞中通过钙独立磷脂酶 A2 组中的胰岛复合脂质

• 批准号: 7355207
• 负责人: SASANKA RAMANADHAM
• 金额: $ 0.94万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355207
• 关键词: ISLET; COMPLEX; LIPID; GROUP; VIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The group VIA phospholipase A2 designated iPLA2B does not require calcium for activation, is stimulated by ATP, and is sensitive to inhibition by a bromoenol lactone suicide substrate (BEL). Several potential functions have been proposed for iPLA2B. Detailed characterization of the iPLA2B protein level reveals that b-cells express multiple isoforms of the enzyme, and our studies involve the hypothesis that different isoforms have different.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。命名为iPLA 2B的VIA族磷脂酶A2不需要钙来活化，受ATP刺激，并且对溴烯醇内酯自杀底物（BEL）的抑制敏感。已经为iPLA 2B提出了几种潜在的功能。iPLA 2B蛋白水平的详细表征揭示了b细胞表达该酶的多种亚型，并且我们的研究涉及不同亚型具有不同的假设。