GROUP VIA PHOSPHOLIPASE A2 IN ENDOPLASMIC RETICULUM STRESS INDUCED APOPTOSIS

内质网应激诱导的细胞凋亡中通过磷脂酶 A2 进行的组

• 批准号: 7355180
• 负责人: SASANKA RAMANADHAM
• 金额: $ 0.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355180
• 关键词: GROUP; VIA; PHOSPHOLIPASE; A2; ENDOPLASMIC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. B-cell apoptosis is a well-recognized process in the development of Type I diabetes and growing evidence suggests that the progressive b-cell dysfunction in TypeII diabetes. Recent reports also indicated that ER stress-induced apoptosis contributes to B-cell loss in diabetes. These findings indicate that iPLA2B participates in ER-stress induced apoptosis, a pathway that promotes b-cell death in diabetes.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。B细胞凋亡在I型糖尿病的发生发展中是一个公认的过程，越来越多的证据表明在II型糖尿病中进行性的B细胞功能障碍。最近的报道也表明，内质网应激诱导的细胞凋亡在糖尿病的B细胞丢失中起作用。这些发现表明，iPLA2B参与了内质网应激诱导的细胞凋亡，这是促进糖尿病b细胞死亡的一条途径。