HIV-PROTEASE INHIBITORS SUPPRESS SKELETAL MUSCLE FATTY ACID OXIDATION

HIV 蛋白酶抑制剂抑制骨骼肌脂肪酸氧化

• 批准号: 8361453
• 负责人: SASANKA RAMANADHAM
• 金额: $ 1.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361453
• 关键词: Fatty Acids; Funding; Grant; HIV; Hepatic; Highly Active Antiretroviral Therapy; Infection; Insulin Resistance; Intramuscular; Lipids; Lipolysis; Mass Spectrum Analysis; National Center for Research Resources; Principal Investigator; Protease Inhibitor; Research; Research Infrastructure; Resources; Skeletal Muscle; Source; United States National Institutes of Health; base; biomedical resource; cost; fatty acid oxidation; fatty acid transport; lipid metabolism; oxidation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Infection with human immunodeficiency virus (HIV) and treatment with HIV-protease inhibitor (PI)-based highly active antiretroviral therapies (HAART) is associated with dysregulated fatty acid and lipid metabolism. Enhanced lipolysis, increased circulating fatty acid levels, and hepatic and intramuscular lipid accumulation appear to contribute to insulin resistance in HIV-infected people treated with PI-based HAART. However, it is unclear whether currently prescribed HIV-PIs directly alter skeletal muscle fatty acid transport, oxidation, and storage.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 人类免疫缺陷病毒（HIV）感染和基于HIV蛋白酶抑制剂（PI）的高效抗逆转录病毒疗法（HAART）治疗与脂肪酸和脂质代谢失调有关。在接受PI为基础的HAART治疗的HIV感染者中，脂解作用增强、循环脂肪酸水平升高以及肝脏和肌内脂质蓄积似乎有助于胰岛素抵抗。然而，目前尚不清楚目前规定的HIV-PI是否直接改变骨骼肌脂肪酸的运输，氧化和储存。