AGE-RELATED CHANGES IN BONE MORPHOLOGY ARE ACCELERATED IN GROUP VIA

VIA 组中与年龄相关的骨形态变化加速

• 批准号: 7954015
• 负责人: SASANKA RAMANADHAM
• 金额: $ 0.56万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954015
• 关键词: Arachidonic Acids; Computer Retrieval of Information on Scientific Projects Database; Event; Fatty Acids; Funding; Grant; Hydrolysis; Institution; Knockout Mice; Mass Spectrum Analysis; Mediator of activation protein; Messenger RNA; Modeling; Morphology; Phospholipases A; Phospholipids; Research; Research Personnel; Resources; Signal Transduction; Source; United States National Institutes of Health; age related; arachidonate; biomedical resource; bone; human PLA2G6 protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phospholipases A(2) (PLA(2)) hydrolyze the sn-2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated knockout (KO) mice lacking the group VIA PLA(2) (iPLA(2)beta), whcih participates in a variety of signaling events; iPLA(s)beta mRNA is expressed in bones of wild-type (WT0 but not KO mice.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 磷脂酶A（2）（PLA（2））水解磷脂中的sn-2脂肪酸取代基，如花生四烯酸，花生四烯酸代谢物是公认的骨建模介质。 我们之前已经产生了缺乏VIA PLA（2）（iPLA（2）beta）组的敲除（KO）小鼠，其参与各种信号传导事件; iPLA（s）beta mRNA在野生型（WT 0）小鼠的骨中表达，但在KO小鼠中不表达。