AGE-RELATED CHANGES IN BONE MORPHOLOGY ARE ACCELERATED IN GROUP VIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 磷脂酶A(2)(pla(2))能从磷脂中水解花生四烯酸等sn-2脂肪酸取代基，花生四烯酸代谢产物是公认的骨模型介体。我们先前已经通过pla(2)(ipla(2)beta)建立了缺乏该组的基因敲除(KO)小鼠，该基因参与了一系列信号事件；ipla(S)betamRNA在野生型(WT0)小鼠的骨骼中表达，但不在KO小鼠的骨骼中表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phospholipases A(2) (PLA(2)) hydrolyze the sn-2 fatty acid substituent, such as arachidonic acid, from phospholipids, and arachidonate metabolites are recognized mediators of bone modeling. We have previously generated knockout (KO) mice lacking the group VIA PLA(2) (iPLA(2)beta), whcih participates in a variety of signaling events; iPLA(s)beta mRNA is expressed in bones of wild-type (WT0 but not KO mice.