Hepatitis B Virus Covalently Closed Circular DNA

乙型肝炎病毒共价闭合环状 DNA

• 批准号: nhmrc : 1004847
• 负责人: A/Pr Allison Jilbert
• 金额: $ 20.2万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hepatitis-b-virus-circular-dna/109074
• 关键词: Hepatitis; Virus; Covalently; Closed; Circular

Worldwide >360 million people have chronic hepatitis B virus (HBV) infection that imparts a 25% lifetime risk of death due to serious liver disease. Current therapies for chronic HBV reduce levels of virus replication but fail to target the stable, nuclear episome, covalently closed circular DNA (cccDNA). The current study will determine what is required to eliminate cccDNA and how current therapies for chronic HBV infection should be modified to achieve this aim.

全球超过 3.6 亿人患有慢性乙型肝炎病毒 (HBV) 感染，终生有 25% 的人因严重肝病而死亡。目前慢性乙型肝炎的治疗方法可降低病毒复制水平，但无法靶向稳定的核游离体、共价闭合环状 DNA (cccDNA)。目前的研究将确定消除 cccDNA 所需的条件以及如何修改现有的慢性 HBV 感染疗法以实现这一目标。