Modulation of aging and age-related behavioral decline

调节衰老和与年龄相关的行为衰退

• 批准号: 6969253
• 负责人: Catherine A Wolkow
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6969253
• 关键词: Caenorhabditis elegans; aging; antioxidants; behavioral /social science research tag; cognition disorders; drug discovery /isolation; drug screening /evaluation; functional ability; life cycle; mitochondria; nervous system disorder chemotherapy; neuropharmacology; performance

A pharmacological approach to minimize declines associated with normal aging is desirable from the standpoint of minimizing the economic and sociological costs of an aging population. However, identifying and characterizing compounds that improve performance in the elderly is expensive and time-consuming. This project aims to quickly identify lead compounds that improve function in old age by using the nematode, C. elegans, to rapidly screen candidate compounds. Current work is focused on characterizing the effects of two types of compounds on the nematode's aging process.

从最小化人口老龄化的经济和社会成本的角度来看，最小化与正常衰老相关的衰退的药理学方法是可取的。然而，识别和表征改善老年人表现的化合物是昂贵且耗时的。该项目旨在通过使用线虫C. elegans，快速筛选候选化合物。目前的工作重点是表征两种类型的化合物对线虫的衰老过程的影响。