Age-related changes in C. elegans nervous system

线虫神经系统与年龄相关的变化

• 批准号: 7132248
• 负责人: Catherine A Wolkow
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7132248
• 关键词: Caenorhabditis elegans; aging; helminth genetics; invertebrate locomotion; muscle contraction; muscle function; neuromuscular junction; neurophysiology; pharynxs

The goal of this project is to identify how aging causes tissue functional and structural declines. These studies are being performed using the nematode, C. elegans, which offers both genetic and cell biological approaches for studying this problem. In C. elegans, aging affects locomotory ability much more dramatically than sensory ability, which is relatively well-maintained during aging. The basis for this age-related locomotory deficit appears to be due, at least in part, to functional declines in the muscles. A second aim of this project is to investigate the basis for aging-related decline of the pharynx, a small, isolated neuromuscular organ in the head of the animal. In the pharynx, aging appears to primarily affect the muscle's ability to respond to neuronal stimulation, and probably does not significantly affect neuronal function. In addition, we demonstrated that muscle contraction is a major contributor to functional declines in this organ during aging. Furthermore, pharynx functional decline could be separated from functional decline in locomotory muscles

该项目的目标是确定衰老如何导致组织功能和结构下降。这些研究是使用线虫C. elegans，它提供了研究这个问题的遗传和细胞生物学方法。In C.在线虫中，衰老对运动能力的影响比感觉能力大得多，而感觉能力在衰老过程中保持得相对较好。这种与年龄相关的运动缺陷的基础似乎是由于，至少部分是由于肌肉功能的下降。 该项目的第二个目的是研究与年龄相关的咽部衰退的基础，咽部是动物头部的一个小的、孤立的神经肌肉器官。在咽部，衰老似乎主要影响肌肉对神经元刺激的反应能力，并且可能不会显著影响神经元功能。此外，我们证明了肌肉收缩是衰老过程中该器官功能下降的主要原因。此外，咽功能下降可以与运动肌肉的功能下降分开

项目成果

What Role do Androgens Play in Endometrial Cancer?

雄激素在子宫内膜癌中发挥什么作用？

• DOI: 10.3390/jpm13020341
• 发表时间: 2023-02-16
• 期刊: JOURNAL OF PERSONALIZED MEDICINE
• 作者: Macek, Petra;Molinari, Nikolaus;Sobocan, Monika;Knez, Jure
• 通讯作者: Knez, Jure

The Prognostic and Predictive Value of Human Gastrointestinal Microbiome and Exosomal mRNA Expression of PD-L1 and IFNγ for Immune Checkpoint Inhibitors Response in Metastatic Melanoma Patients: PROTOCOL TRIAL.

• DOI: 10.3390/biomedicines11072016
• 发表时间: 2023-07-18
• 期刊: BIOMEDICINES
• 影响因子: 4.7
• 作者: Erman, Ana;Ignjatovic, Marija;Leskovsek, Katja;Miceska, Simona;Tratar, Ursa Lampreht;Bosnjak, Masa;Prevodnik, Veronika Kloboves;Cemazar, Maja;Sekulovic, Lidija Kandolf;Avgustin, Gorazd;Ocvirk, Janja;Mesti, Tanja
• 通讯作者: Mesti, Tanja

Biomarkers for Outcome in Metastatic Melanoma in First Line Treatment with Immune Checkpoint Inhibitors.

• DOI: 10.3390/biomedicines11030749
• 发表时间: 2023-03-01
• 期刊: Biomedicines
• 影响因子: 4.7