SENSITIVE TO LOW PPM AND REVERSIBLE SENSOR FOR CO

描述(申请人提供)：根据辛辛那提儿童医院医学中心的报告，一氧化碳是导致意外中毒死亡的首要原因。最近的估计显示，每年有3,500-4,000人死于意外接触CO；另有10,000人寻求医疗护理。一氧化碳暴露对未出生的婴儿、婴儿和儿童尤其危险，因为他们的身体更小，代谢更快--他们吸收一氧化碳的速度更快，水平更低。胎儿体内一氧化碳的毒性水平可能比母亲高出十倍。可能的缓解需要一个可靠的、早期预警的CO探测器。高灵敏度和完全可逆性是目前市场上的CO检测器严重缺乏的两个理想特性。在第一阶段，InnoSense LLC已经展示了一种基于薄膜的CO传感器，它对5ppm的CO在5秒内做出响应。传感器也在5秒内显示出可逆性。第二阶段项目将：(A)微调CO指标，以将响应/恢复时间缩短50%或更多；(B)进行广泛的性能研究，以评估该传感器在典型家庭中可能发现的污染物存在的情况下可靠地工作多长时间和多大效率。公共卫生相关性：对CO第二阶段项目的低PPM和可逆传感器的敏感性描述第二阶段项目的关键目标是微调CO指标的制定。第二阶段的工作建立在第一阶段利用红豆基质开发的薄膜配方的基础上。这种配方策略与纤维束方法一起补充了首席调查员早期涵盖一氧化碳指示器基本成分的专利。总而言之，传感平台预计将提供具有多分析物检测能力的设备。InnoSense LLC系统地组装和开发了化学传感器能力、材料科学专业知识以及自制的光电测试和测量设备。该公司还组建了一支有能力的科学团队，拥有开发商业上可行的传感器产品的70人年的经验。鉴于这些资源及其在医学相关传感器领域的承诺，InnoSense LLC处于独特的地位，可以有效地利用第二阶段的资金来研究这种救生设备的开发，特别是针对我们人群中的弱势群体--老年人、婴儿和怀有未出生婴儿的孕妇。

DESCRIPTION (provided by applicant): According to the Cincinnati Children's Hospital Medical Center report, carbon monoxide is the leading cause of accidental death by poisoning. More recent estimates reveal 3,500-4,000 people die each year due to accidental CO exposure; and an additional 10,000 seek medical attention. Carbon monoxide exposure is especially dangerous for unborn babies, infants, and children because they have smaller bodies and faster metabolisms -- they absorb carbon monoxide quicker and at lower levels. Toxic levels of carbon monoxide can be up to ten times higher in the fetus than the mother. Possible mitigation requires a reliable, early warning CO detector. High sensitivity and complete reversibility are two desirable characteristics that are lacking severely in CO detectors currently available in the market. During Phase I, InnoSense LLC has demonstrated a thin film-based CO sensor sensitive to 5 ppm CO responding within five seconds. The sensor has also shown reversibility within five seconds. The Phase II project would: (a) Fine-tune the CO indicator for shortening the response/recovery times by 50% or more, (b) Conduct extensive performance studies to evaluate for how long and how effectively this sensor would perform reliably in the presence of contaminants likely to be found in a typical household. PUBLIC HEALTH RELEVANCE: Sensitive to Low PPM and Reversible Sensor for CO Phase II Project Narrative A key goal of the Phase II project is to fine-tune the CO indicator formulation. The Phase II work builds on the thin film formulation developed during Phase I utilizing ormosil matrix. This formulation strategy along with the fiber bundle approach complements the Principal Investigator's earlier patents covering basic ingredients of the CO indicator. Together, the sensing platform is expected to offer devices that would have multi-analyte detection capability. InnoSense LLC has systematically assembled and developed chemical sensor capabilities, materials science expertise, and home-built optoelectronic test and measurement devices. The company has also assembled a competent scientific team having seventy person-years of experience developing commercially viable sensor products. Given these resources and its commitment to the area of medically relevant sensors, InnoSense LLC is uniquely positioned to make effective use of the Phase II funding to study development of this life-saving device especially for a vulnerable portion of our populace - the elderly, infants and pregnant women carrying the unborn.