SENSITIVE TO LOW PPM AND REVERSIBLE SENSOR FOR CO

描述（由申请人提供）：根据辛辛那提儿童医院医疗中心的报告，一氧化碳是中毒意外死亡的主要原因。最近的估计显示，每年有3500至4000人因意外接触一氧化碳而死亡；另有1万人寻求医疗救助。一氧化碳暴露对未出生的婴儿、婴儿和儿童尤其危险，因为他们的身体更小，新陈代谢更快——他们吸收一氧化碳的速度更快，浓度也更低。胎儿体内有毒的一氧化碳含量可能比母亲高十倍。可能的缓解需要可靠的早期预警一氧化碳探测器。高灵敏度和完全可逆性是目前市场上CO探测器严重缺乏的两个理想特性。在第一阶段，InnoSense LLC展示了一种基于薄膜的CO传感器，对5 ppm的CO敏感，在5秒内响应。传感器还显示了5秒内的可逆性。第二期项目将：(a)微调CO指标，将响应/恢复时间缩短50%或更多，(b)进行广泛的性能研究，以评估该传感器在典型家庭中可能存在污染物的情况下可靠运行的时间和效率。公共卫生相关性：对CO第二期项目的低PPM敏感和可逆传感器叙述第二期项目的一个关键目标是微调CO指标的制定。第二阶段的工作是建立在第一阶段利用ormosil基质开发的薄膜配方的基础上。这种配方策略以及纤维束方法补充了首席研究员早期的专利，涵盖了CO指示剂的基本成分。总之，传感平台预计将提供具有多种分析物检测能力的设备。InnoSense LLC系统地组装和开发了化学传感器能力，材料科学专业知识和自制光电测试和测量设备。公司还组建了一支有能力的科学团队，拥有70人年的开发商业可行传感器产品的经验。鉴于这些资源及其对医学相关传感器领域的承诺，InnoSense LLC具有独特的优势，可以有效利用第二阶段资金来研究开发这种救生设备，特别是针对我们人口中的弱势群体——老年人、婴儿和携带未出生胎儿的孕妇。

DESCRIPTION (provided by applicant): According to the Cincinnati Children's Hospital Medical Center report, carbon monoxide is the leading cause of accidental death by poisoning. More recent estimates reveal 3,500-4,000 people die each year due to accidental CO exposure; and an additional 10,000 seek medical attention. Carbon monoxide exposure is especially dangerous for unborn babies, infants, and children because they have smaller bodies and faster metabolisms -- they absorb carbon monoxide quicker and at lower levels. Toxic levels of carbon monoxide can be up to ten times higher in the fetus than the mother. Possible mitigation requires a reliable, early warning CO detector. High sensitivity and complete reversibility are two desirable characteristics that are lacking severely in CO detectors currently available in the market. During Phase I, InnoSense LLC has demonstrated a thin film-based CO sensor sensitive to 5 ppm CO responding within five seconds. The sensor has also shown reversibility within five seconds. The Phase II project would: (a) Fine-tune the CO indicator for shortening the response/recovery times by 50% or more, (b) Conduct extensive performance studies to evaluate for how long and how effectively this sensor would perform reliably in the presence of contaminants likely to be found in a typical household. PUBLIC HEALTH RELEVANCE: Sensitive to Low PPM and Reversible Sensor for CO Phase II Project Narrative A key goal of the Phase II project is to fine-tune the CO indicator formulation. The Phase II work builds on the thin film formulation developed during Phase I utilizing ormosil matrix. This formulation strategy along with the fiber bundle approach complements the Principal Investigator's earlier patents covering basic ingredients of the CO indicator. Together, the sensing platform is expected to offer devices that would have multi-analyte detection capability. InnoSense LLC has systematically assembled and developed chemical sensor capabilities, materials science expertise, and home-built optoelectronic test and measurement devices. The company has also assembled a competent scientific team having seventy person-years of experience developing commercially viable sensor products. Given these resources and its commitment to the area of medically relevant sensors, InnoSense LLC is uniquely positioned to make effective use of the Phase II funding to study development of this life-saving device especially for a vulnerable portion of our populace - the elderly, infants and pregnant women carrying the unborn.