SENSITIVE TO LOW PPM AND REVERSIBLE SENSOR FOR CO

对低 PPM 敏感且可逆 CO 传感器

• 批准号: 7694302
• 负责人: Kisholoy Goswami
• 金额: $ 36.54万
• 依托单位: INNOSENSE, LLC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7694302
• 关键词: Acetone; Acute; Alcohols; American; Ammonia; Area; Arts; Brain; Buffers; Carbon Monoxide; Carbon Monoxide Poisoning; Cessation of life; Characteristics; Chemicals; Chemistry; Child; Collaborations; Color; Complement; Detection; Development; Devices; Drug Formulations; Elderly; Exposure to; Fetus; Fiber; Film; Fire - disasters; Funding; Gases; General Population; Goals; Grant; Healthcare Systems; Home environment; Household; Humidity; Hydrocarbons; Immune; Infant; Lead; Legal patent; Life; Marketing; Measurement; Measures; Medical; Medical center; Mental Health; Metabolism; Methodology; Mothers; Natural regeneration; Organ; Oxidation-Reduction; Oxygen; Patients; Pediatric Hospitals; Performance; Persons; Phase; Poisoning; Positioning Attribute; Pregnant Women; Principal Investigator; Process; Reaction Time; Recovery; Reporting; Reproducibility; Resources; Rights; Risk; Science; Source; Survivors; Temperature; Testing; Time; United States; United States National Institutes of Health; Work; age group; base; detector; experience; fetus cell; instrument; killings; medical attention; neuropsychiatry; optical sensor; prenatal; public health relevance; response; sensor; statistics; toxicant; vapor

DESCRIPTION (provided by applicant): According to the Cincinnati Children's Hospital Medical Center report, carbon monoxide is the leading cause of accidental death by poisoning. More recent estimates reveal 3,500-4,000 people die each year due to accidental CO exposure; and an additional 10,000 seek medical attention. Carbon monoxide exposure is especially dangerous for unborn babies, infants, and children because they have smaller bodies and faster metabolisms -- they absorb carbon monoxide quicker and at lower levels. Toxic levels of carbon monoxide can be up to ten times higher in the fetus than the mother. Possible mitigation requires a reliable, early warning CO detector. High sensitivity and complete reversibility are two desirable characteristics that are lacking severely in CO detectors currently available in the market. During Phase I, InnoSense LLC has demonstrated a thin film-based CO sensor sensitive to 5 ppm CO responding within five seconds. The sensor has also shown reversibility within five seconds. The Phase II project would: (a) Fine-tune the CO indicator for shortening the response/recovery times by 50% or more, (b) Conduct extensive performance studies to evaluate for how long and how effectively this sensor would perform reliably in the presence of contaminants likely to be found in a typical household. PUBLIC HEALTH RELEVANCE: Sensitive to Low PPM and Reversible Sensor for CO Phase II Project Narrative A key goal of the Phase II project is to fine-tune the CO indicator formulation. The Phase II work builds on the thin film formulation developed during Phase I utilizing ormosil matrix. This formulation strategy along with the fiber bundle approach complements the Principal Investigator's earlier patents covering basic ingredients of the CO indicator. Together, the sensing platform is expected to offer devices that would have multi-analyte detection capability. InnoSense LLC has systematically assembled and developed chemical sensor capabilities, materials science expertise, and home-built optoelectronic test and measurement devices. The company has also assembled a competent scientific team having seventy person-years of experience developing commercially viable sensor products. Given these resources and its commitment to the area of medically relevant sensors, InnoSense LLC is uniquely positioned to make effective use of the Phase II funding to study development of this life-saving device especially for a vulnerable portion of our populace - the elderly, infants and pregnant women carrying the unborn.

描述（由申请人提供）：根据辛辛那提儿童医院医疗中心的报告，一氧化碳是中毒意外死亡的主要原因。最近的估计显示，每年有3，500 - 4，000人因意外接触CO而死亡;另有10，000人寻求医疗照顾。一氧化碳暴露对未出生的婴儿，婴儿和儿童特别危险，因为他们的身体较小，新陈代谢较快-他们吸收一氧化碳更快，水平更低。胎儿体内的一氧化碳毒性水平可能比母亲高出十倍。可能的缓解措施需要可靠的早期预警CO探测器。高灵敏度和完全可逆性是目前市场上可用的CO检测器严重缺乏的两个期望特性。在第一阶段，InnoSense LLC已经展示了一种基于薄膜的CO传感器，该传感器对5 ppm CO敏感，在5秒内响应。传感器还显示在5秒内可逆。第二阶段项目将：（a）微调一氧化碳指示器，将响应/恢复时间缩短50%或更多，（B）进行广泛的性能研究，以评估在典型家庭中可能发现的污染物存在的情况下，该传感器将可靠地工作多久和有效程度如何。公共卫生相关性：第二阶段项目的一个关键目标是微调一氧化碳指标的制定。第二阶段的工作是建立在第一阶段利用ormosil基质开发的薄膜配方基础上的。这种配方策略沿着纤维束方法补充了主要研究者的早期专利，涵盖了CO指示剂的基本成分。总之，传感平台预计将提供具有多分析物检测能力的设备。InnoSense LLC系统地组装和开发了化学传感器功能，材料科学专业知识和自制光电测试和测量设备。该公司还组建了一支有能力的科学团队，拥有70年开发商业上可行的传感器产品的经验。鉴于这些资源及其对医疗相关传感器领域的承诺，InnoSense LLC处于独特的地位，可以有效利用第二阶段资金来研究这种救生设备的开发，特别是针对我们人口中的弱势群体-老年人，婴儿和孕妇携带未出生的婴儿。