FIBER GRATING-BASED CHEMOSELECTIVE AND REVERSIBLE SENSOR ARRAY

描述（由申请人提供）：InnoSense LLC （ISL）提议研究一组选择性元件，这些元件通过一组配置在并行架构中的长周期光栅（LPG）光纤光耦合到光传播。目标是研究一种有潜力开发出高灵敏度（10 ppb或更高）和可靠（百万分之一的错误读数）设备的技术。这将使第一反应者能够在尿液、唾液或汗液等生物液体中检测化学战剂（CWAs）的代谢物。液化石油气将被化学选择性碳硅氧烷聚合物包裹，这种聚合物是由太平洋西北国家实验室（PNNL）合理设计的，专门用于使用表面声波（SAW）平台检测碳was。这种化学选择性涂层的跨平台利用将允许ISL利用小波变换来处理3D数据集（波长、振幅和时间轴）。传感器响应将使用神经网络多变量算法进行后处理。已经制定了方案来研究该阵列在加标人工尿液样本中的性能参数。还将进行研究，以确定温度和尿液成分（如尿素、尿色素和尿酸）在尿液中浓度超过正常范围上限时的影响。这份快速通道SBIR拨款申请建议研究一种传感器阵列，以供第一响应者使用。这项工作的影响将是检测尿液等生物液体中的化学战剂代谢物。这种传感器阵列也是监测医疗保健和环境污染物的一种使能技术。这项研究结果的传播将增加科学知识体系，产生辅助传感器系统，并提供额外的商业/社会效益。

DESCRIPTION (provided by applicant): InnoSense LLC (ISL) proposes to investigate an array of selective elements that are optically coupled to light propagation through a set of long period grating (LPG) fibers configured in a parallel architecture. The goal is to study a technique that has the potential for developing a highly sensitive (10 ppb or better) and reliable (one false reading in a million) device. This will allow the first responders to detect metabolites of chemical warfare agents (CWAs) in biological fluids such as urine, saliva or sweat. The LPGs will be coated with chemoselective carbosiloxane polymers that have been designed rationally at the Pacific Northwest National Laboratory (PNNL) for detecting CWAs specifically using a surface acoustic wave (SAW) platform. This cross-platform utilization of the chemoselective coatings will allow ISL to utilize wavelet transformations to process 3D dataset (wavelength, amplitude and time axes). The sensor response will be post-processed using neural network multivariate algorithm. Protocols have been developed to study performance parameters of the array in spiked artificial urine samples. Studies will also be made to determine the impact of temperature, and urine components (e.g., urea, urochrome and uric acid) at concentrations exceeding upper limit of the normal range in urine. This Fast-Track SBIR Grant Application proposes to study a sensor array for potential use by the first responders. The impact of this work will be detection of chemical warfare agent metabolites in biological fluids such as urine. This sensor array is also an enabling technology for monitoring health care and environmental pollutants. Dissemination of the finding from this study will add to the body of scientific knowledge, spawn subsidiary sensor systems and provide additional commercial/societal benefits.