Asymmetric Assembly of Cobalt Metallocenes - Accessible Building Blocks for Novel Catalysts

钴茂金属的不对称组装——新型催化剂的可用构建模块

• 批准号: EP/C511034/2
• 负责人: Chris Richards
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FC511034%2F2
• 关键词: Asymmetric; Assembly; Cobalt; Metallocenes; Accessible

Molecules that exist in 'handed' form are of growing importance to many research areas, not least the pharmaceutical industry where sales of such compounds now exceed $100 billion per annum. 'Handed' molecules exist in two non-superimposable mirror image forms of which only one usually displays the desired property such as an ability to mediate biological activity. One of the most efficient and cost effective means to generate such molecules is to employ a small quantity of a metal/ligand catalyst that selectively generates one 'handed' form over the alternative. Central to this strategy is the ligand which contains the information required to successfully control the reaction taking place at the metal, to which it is attached. Thus many different ligand types have been synthesised and tested, yet it is striking how certain groups, or privileged structures as they have been coined, are successful for a wide range of applications. One of these groups is the metallocenes, normally derivatives of iron-based compounds called ferrocenes. In this proposal a new strategy is outlined for the synthesis of cobalt based metallocenes that is significantly simpler than the existing ferrocene methodology. Furthermore, it has much greater variability and flexibility that will enable rapid access to, and optimisation of, a ligand for a given metal catalysed 'handed' synthesis.

以“手”形式存在的分子对于许多研究领域越来越重要，尤其是制药行业，此类化合物的销售额目前每年超过 1000 亿美元。 “手性”分子以两种不可重叠的镜像形式存在，其中通常只有一种表现出所需的特性，例如介导生物活性的能力。产生此类分子的最有效和最具成本效益的方法之一是使用少量的金属/配体催化剂，选择性地产生一种“手性”形式而不是替代形式。该策略的核心是配体，它包含成功控制其所附着的金属上发生的反应所需的信息。因此，许多不同的配体类型已经被合成和测试，但令人惊讶的是某些基团或它们所创造的特权结构在广泛的应用中取得了成功。其中一类是茂金属，通常是称为二茂铁的铁基化合物的衍生物。该提案概述了一种合成钴基茂金属的新策略，该策略比现有的二茂铁方法要简单得多。此外，它具有更大的可变性和灵活性，可以快速获取和优化给定金属催化“手控”合成的配体。

项目成果

Synthesis of racemic palladacycles from 2-ferrocenylphenylphosphines

• DOI: 10.1016/j.jorganchem.2014.10.004
• 发表时间: 2015
• 期刊: Journal of Organometallic Chemistry
• 影响因子: 2.3
• 作者: Ketankumar J. Panchal;Jahangir Amin;Jahangir Amin;F. Roca;M. Motevalli;P. Horton;S. Coles;C. Richards

Application of the Nicholas reaction to the synthesis of dicobalt hexacarbonyl complexed diyne ethers

尼古拉斯反应在六羰基二钴络合二炔醚合成中的应用

• DOI: 10.1016/j.jorganchem.2014.10.030
• 发表时间: 2015
• 期刊: Journal of Organometallic Chemistry
• 影响因子: 2.3
• 作者: Amin J