Catalyst Diversity from Chiral Palladacycles

手性钯环的催化剂多样性

• 批准号: EP/N019393/1
• 负责人: Chris Richards
• 金额: $ 41.22万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN019393%2F1
• 关键词: Catalyst; Diversity; Chiral; Palladacycles

Catalytic methodologies have a very major impact on improving the efficiency and cost effectiveness of synthesis, a key (usually the key) technology for the development of new medicines, agrochemicals, materials, fragrances and, in turn, further catalysts. This programme will generate a platform for the discovery of chiral palladium catalysts for use in asymmetric synthesis based upon a new method of catalyst formation. This will allow numerous catalysts to be generated in just one step from palladium-based complexes, the synthesis of which has been pioneered within the Richards group. Access to a diverse array of palladium catalysts will enable the optimisation of selectivity and the minimisation of the quantity of catalyst required in a host of reactions. In addition, the new catalyst generation protocol will enable facile immobilisation, boosting further the sustainability of the chemistry through catalyst recovery and reuse. The new platform will be applied to the selective synthesis of novel and varied chiral (i.e. handed) structures, diversity generation lying at the heart of the process of discovering new bioactive compounds for application in drug discovery programmes.

催化方法对提高合成效率和成本效益具有非常重大的影响，合成是开发新药物、农用化学品、材料、香料以及进一步催化剂的关键（通常是关键）技术。该计划将为发现用于基于新的催化剂形成方法的不对称合成的手性钯催化剂提供平台。这将使钯基络合物只需一步即可生成多种催化剂，而这种络合物的合成是由理查兹小组率先进行的。使用各种钯催化剂将能够优化选择性并最大限度地减少许多反应所需的催化剂数量。此外，新的催化剂生成协议将实现轻松固定，通过催化剂回收和再利用进一步提高化学的可持续性。新平台将应用于选择性合成新颖且多样的手性（即手性）结构，多样性生成是发现新生物活性化合物用于药物发现计划的过程的核心。

项目成果

Application of a Ferrocene-Based Palladacycle Precatalyst to Enantioselective Aryl-Aryl Kumada Coupling

• DOI: 10.1002/ejic.202101077
• 发表时间: 2022-02-17
• 期刊: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
• 影响因子: 2.3
• 作者: Arthurs, Ross A.;Hughes, David L.;Richards, Christopher J.
• 通讯作者: Richards, Christopher J.

Synthesis of Diastereomeric Bis(oxazoline) Ligands Derived from (S,S)-1,1'-Bis(4-isopropyloxazolin-2-yl)ferrocene

(S,S)-1,1-双(4-异丙基恶唑啉-2-基)二茂铁衍生的非对映体双(恶唑啉)配体的合成

• DOI: 10.1055/s-0036-1589163
• 发表时间: 2018
• 期刊: Synlett
• 影响因子: 2
• 作者: Richards C

Copper(I) Complexes of P -Stereogenic Josiphos and Related Ligands

P-立构 Josiphos 的铜 (I) 配合物及相关配体

• DOI: 10.1002/ejoc.202100146
• 发表时间: 2021
• 期刊: European Journal of Organic Chemistry
• 影响因子: 2.8
• 作者: Arthurs R

Deuterium as a Stereochemically Invisible Blocking Group for Chiral Ligand Synthesis.

• DOI: 10.1021/acs.orglett.6b03874
• 发表时间: 2017-01
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: Ross A Arthurs;C. Richards

Stereoselective and Stereospecific Reactions of Cobalt Sandwich Complexes: Synthesis of a New Class of Single Enantiomer Bulky Planar Chiral P-N and P-P Ligands

钴夹心配合物的立体选择性和立体特异性反应：合成一类新型单一对映体大平面手性 P-N 和 P-P 配体

• DOI: 10.1002/chem.201705113
• 发表时间: 2018
• 期刊: Chemistry - A European Journal
• 作者: Arthurs R