Privileged Metallocene Catalysts for Asymmetric Synthesis

用于不对称合成的特殊茂金属催化剂

• 批准号: EP/E06356X/1
• 负责人: Chris Richards
• 金额: $ 23.35万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE06356X%2F1
• 关键词: Privileged; Metallocene; Catalysts; Asymmetric; Synthesis

Bulky cobalt metallocenes have recently found application in a number of asymmetric transformations characterised by high enantioselectivity. The further development of this area is hampered by the absence of a general methodology for the synthesis of planar chiral derivatives. A general solution to this problem is proposed involving asymmetric desymmetrisation by either metal catalysed cross-coupling and/or enantioselective halogen-metal exchange. The resulting non-racemic products will be used for the synthesis of representative P, PN and PP ligands, and also for the generation of palladium based and 'organocatalytic' rearrangement catalysts for application in asymmetric synthesis.

大体积钴茂最近发现应用于许多具有高对映选择性的不对称转化。平面手性衍生物的合成缺乏通用的方法，阻碍了这一领域的进一步发展。这个问题的一般解决方案，提出涉及不对称desymmetrisation通过金属催化的交叉偶联和/或对映选择性卤素金属交换。所得的非外消旋产物将用于合成代表性的P、PN和PP配体，并且还用于产生钯基和“有机催化”重排催化剂以用于不对称合成。

项目成果

Enantioselective synthesis and application to the allylic imidate rearrangement of amine-coordinated palladacycle catalysts of cobalt sandwich complexes.

• DOI: 10.1002/chem.201302922
• 发表时间: 2013-12-23
• 期刊: Chemistry (Weinheim an der Bergstrasse, Germany)
• 作者: Cassar DJ;Ilyashenko G;Ismail M;Woods J;Hughes DL;Richards CJ
• 通讯作者: Richards CJ