SPORE in Breast Cancer

描述（由申请人提供）：阿拉巴马大学伯明翰分校（UAB）乳腺癌孢子项目的战略计划是了解乳腺癌的生物学，并将这些知识转化为临床早期检测、预防、预后和开发新疗法。SPORE正在几个转化研究领域进行投资，为了实现其目标，已经聚集了基础和临床科学家，包括分子/细胞生物学家、病理学家、医学/外科肿瘤学家、新技术开发专家和生物统计学家。《孢子》由五大项目和三大核心组成。项目包括：1)UAB类维生素a预防乳腺癌；2) BRMS1：预后标志物和治疗靶点；3) KLF4信号通路中的乳腺癌生物标志物；4)阻断乳腺癌激素调控的多肽；5) DR5抗体治疗乳腺癌。个人项目的转化研究重点包括：癌症生物学（#2-4）；治疗/生存（# 2,# 4-5）；诊断/预后（#2,#3）；预防（#1）。核心是A)行政/临床试验；B)生物统计学/数据库;C)组织资源/免疫病理/分子分析。所有的项目都以人类乳腺癌为重点，涉及基础和临床科学家，与其他项目互动，并利用核心资源。目前，十项由孢子发起的临床试验正在进行中，或将在未来几个月内开始积累受试者。SPORE已经开发并正在维护一个综合的乳腺癌数据库，该数据库将患者、肿瘤和治疗数据与患者特定的组织和血液标本联系起来。创新的发展研究和癌症发展项目带来了新的研究人员进入并刺激了孢子。UAB和UAB综合癌症中心对这些项目的大力支持增加了它们的影响。SPORE参与了Breast SPORE“圆桌会议”和nci赞助的年度SPORE研讨会的内部工作。实现这项建议的宗旨和目标将导致乳腺癌的发病率、发病率和死亡率大幅下降。

DESCRIPTION (provided by applicant): The strategic plan of the University of Alabama at Birmingham (UAB) SPORE in Breast Cancer is to understand the biology of breast cancer and to translate this knowledge into the clinic for early detection, prevention, prognosis, and development of new therapies. The SPORE is investing in several translational research areas and to achieve its goals, basic and clinical scientists have been assembled, including molecular/cell biologists, pathologists, medical/surgical oncologists, experts in the development of new technologies, and biostatisticians. The SPORE consists of five major projects and three supporting cores. The projects are: 1) UAB Rexinoids for Breast Cancer Prevention; 2) BRMS1: Prognostic Marker and Therapeutic Target; 3) Breast Cancer Biomarkers in the KLF4 Signaling Pathway; 4) Peptides Blocking Hormonal Control in Breast Cancer; and 5) DR5 Antibody therapy for Breast Cancer. The translational research focus on the individual projects include: cancer biology (#2-4); therapy/survival (# 2, # 4-5); diagnosis/prognosis (#2, #3); and prevention (#1). The Cores are A) Administrative/Clinical Trials; B) Biostatistics/Database; and C) Tissue resources /Immunopathology /Molecular Assays. All of the projects focus on human breast cancer, involve basic and clinical scientists, interact with the other projects, and utilize core resources. Currently, ten SPORE-initiated clinical trials are underway or will begin accruing subjects within the next few months. The SPORE has developed and is maintaining a comprehensive breast cancer database that correlates patient, tumor, and treatment data with patient-specific tissue and blood specimens. Innovative Developmental Research and Cancer Development Programs bring new investigators into and stimulate the SPORE. The strong support of these programs by UAB and the UAB Comprehensive Cancer Center increase their impact. The SPORE participates in the inter-SPORE efforts of the Breast SPORE "round-table" and the annual NCI-sponsored SPORE workshop. Achievement of the aims and objectives of this proposal will result in a major decrease in the incidence, morbidity, and mortality of breast cancer.