Research Training Program in Surgical Oncology

描述（由申请人提供）：该竞争性更新最初于2002年获得资助，目前正在完成第二个五年周期的第四年（第10年）。该T32建立在外科和妇产科各肿瘤学科的临床和科学优势基础上。这两个部门与UAB综合癌症中心的合作伙伴关系提供了一个合作实验室科学的综合基础设施，涵盖了基础分子发现，将科学研究从实验室转移到临床应用和转化研究。这种培训环境增强了肿瘤生物学和免疫学，人类遗传学，自身免疫和炎症，转化临床和成果研究中的内部协作，无缝跨部门举措。 该研究计划的战略目标特别强调在早期博士后阶段培养新生的，有前途的年轻外科科学家，并且他们正在接受ACGME批准的外科或妇科肿瘤培训计划。因此，这个T-32计划协调有前途的博士后ACGME居民候选人谁将渴望学术教师职位的指导，并将加强UAB的特殊辅导环境。这个T-32补助金代表了UAB四个SPORE项目之间的教师合作和协同科学兴趣的机制。在程序上，有效的跨学科研究经验是通过导师所需的教学和个人研究计划所需的课程工作的强制性结合来实现的。在统计学和研究的道德行为课程工作是在这个竞争性的更新与临床和转化科学中心（CCTS）和博士后教育办公室在granitary，手稿写作和转化研究提供的正式指令增强。在过去的五年中，22 ACGME住院实习生在外科和妇科肿瘤是由这个T-32机制的支持。由于研究生外科培训接近7-10年，而T-32受训者在职业生涯的早期阶段进行研究，因此相当多的受训者在学术任命之前仍然有超过5年的外科培训。因此，经过10年的持续资助，我们才刚刚开始看到我们项目的学术成功。在过去的10年里，有36名学员完成了T-32培训，其中70%的住院医师继续从事学术生物医学研究和实践/培训。此外，在过去五年中，T-32一直是性别平衡的，包括17%的代表性不足的少数民族。在过去的十年中，T32为学员提供了持续的坚定承诺，并监督和鼓励对调查和学术界职业的相互承诺。这反映在那些谁已经完成了在外科，肿瘤学科和妇产科的其他医学院的学术教师职位的培训。因此，每年要求继续为6名博士后实习生提供资金。 公共卫生相关性： 这是Ruth L的竞争性更新。Kirschstein国家研究服务奖（NRSA）机构研究培训补助金（T32）在UAB的外科肿瘤学研究培训计划将使跨学科，研究发现和转化科学。该计划提供了从临床医学到综合的无缝过渡，实习生的指导，然后回到临床医学。这种合作的科学经验允许从基础分子发现到转化临床研究的最先进应用的一系列研究选择。Surgica肿瘤学研究培训的培训计划包括一个成熟的，专门的，经验丰富的基础和临床教师。该学院包括医学科学家和高级博士，他们拥有进一步增强强大的教师互动动态的专业知识，以提供全面的指导环境。我们努力的成功记录是有效的学员促进和外科肿瘤学事业发展的最佳证明，在计划的所有阶段。在过去的五年资助周期中，该计划实现了性别平衡（33%为女性），并包括15%的代表性不足的少数民族，从而实现了对科学平衡的肿瘤学培训计划的多样性和卓越性的计划承诺，重点是外科科学。重要的是，为留住学术外科肿瘤学、外科学科和妇科肿瘤学的学员所做的努力非常出色，86%的学员继续担任大学临床和研究职位。目前的提案扩大和发展了我们的基础设施和组织，不仅仅是重新制定过去的提案;这 更新申请是对我们方案的重新设计，更好地选择导师，修订课程，改进评估和监测机制。

DESCRIPTION (provided by applicant): This competitive renewal was originally funded in 2002, and is now completing the fourth year of its second five-year cycle (10th year). This T32 builds upon established clinical and scientific strengths in various oncologic disciplines of the Departments of Surgery and Obstetrics/Gynecology. The partnership of both Departments with UAB Comprehensive Cancer Center provides an integrated infrastructure of collaborative bench science that spans fundamental molecular discovery to move scientific inquiry from bench-to-bedside for applied clinical and translational research. This training environment enhances the intra-collaborative, seamless trans-departmental initiatives available in Tumor Biology and Immunology, Human Genetics, Autoimmunity and Inflammation, Translational Clinical and Outcomes Research. The strategic goals of the research plan have special emphasis on the training of nascent, promising young Surgical-Scientists in their early post-doctoral years and who are in ACGME-approved training programs in Surgery or Gynecologic Oncology. Thus, this T-32 program coordinates the mentorship of promising post- doctoral ACGME resident-candidates who will aspire to academic faculty positions and will strengthen UAB's exceptional mentoring environment. This T-32 grant represents a mechanism for faculty collaboration and synergistic scientific interests among its four SPORE programs at UAB. Programmatically, an effective interdisciplinary research experience is implemented by the obligatory incorporation of the required teaching via mentors and the required course work for individual research plans. Course work in statistics and ethical conduct of research is augmented in this competitive renewal with formal instruction provided by the Center for Clinical and Translational Science (CCTS) and the Office of Post-Doctoral Education in grantsmanship, manuscript writing, and translational research. Over the past five years, 22 ACGME resident-trainees in Surgery and Gynecologic Oncology were supported by this T-32 mechanism. Because post-graduate surgical training approaches 7-10 years, and T-32 Trainees conduct research in the early stages of their career, a significant number of trainees still have >5 years of surgical training remaining prior to academic appointment. Therefore, we are just beginning to see the academic success of our program after 10 years of continuous funding. In the past 10 years, there have been 36 trainees that have completed their T-32 training with 70 % of these residents continuing in academic biomedical research and practice / training. Moreover, in the past five years, this T-32 has been gender-balanced and has included 17% under-represented minorities. This T32 has, over the past ten years, provided continual strong commitment to trainees with oversight and encouragement of reciprocal commitment to careers in investigation and academia. This is reflected by those who have completed training with academic faculty positions in other Schools of Medicine within Departments of Surgery, its oncology disciplines, and Obstetrics/Gynecology. Continued funding is therefore requested annually for 6 post-doctoral resident-trainees. PUBLIC HEALTH RELEVANCE: This competitive renewal of the Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) Research Training Program in Surgical Oncology at UAB will enable interdisciplinary, research in discovery and translational science. The program provides a seamless transition from clinical medicine to integrated, mentorship of the resident-trainee and then back to clinical medicine. This collaborative scientific experience allows a range of research options from fundamental molecular discovery to the most advanced applications of translational clinical research. The training plan for Research Training in Surgica Oncology incorporates an established, dedicated, and experienced basic and clinical faculty. This faculty includes surgical-scientists and senior Ph.D.s who have expertise that further enhances the robust faculty interaction dynamic to provide a comprehensive mentoring environment. The successful track record of our efforts is the best demonstration of effective mentee promotion and surgical oncology carrer development , in all phases of the Program. Over the past five-year funding cycle, this program has been gender-balanced (33% women) and has included 15% under-represented minorities, thus enabling the programmatic commitment to diversity and excellence in a scientifically-balanced oncology training program focused upon Surgical Science. Importantly, the efforts to achieve retention of trainees in academic surgical oncology, its surgical disciplines and gynecological oncology has been outstanding ,with 86% continuing in university clinical and research positions .The current proposal expands and develops our infrastructure and organization, with more than a mere reformulation of past submissions; this renewal application constitutes a fresh redesign of our program with better selection of mentors, a revised curriculum and improved evaluation and monitoring mechanisms.