Research Training Program in Surgical Oncology

说明(申请人提供)：本次竞争性续签最初于2002年获得资助，现已完成第二个五年期周期的第四个年头(第10个年头)。这款T32建立在外科和产科/妇科的各种肿瘤学学科的临床和科学实力的基础上。这两个部门与UAB综合癌症中心的合作为协作基础科学提供了一个集成的基础设施，该基础设施跨越了基础分子发现，将科学研究从实验室转移到床边，用于应用临床和转化研究。这种培训环境加强了在肿瘤生物学和免疫学、人类遗传学、自身免疫和炎症、转化性临床和结果研究方面的内部协作和无缝跨部门倡议。该研究计划的战略目标特别强调对初出茅庐、有前途的年轻外科科学家的培训，这些年轻的外科科学家在他们早期的博士后生涯中，正在参加ACGME批准的外科或妇科肿瘤学培训计划。因此，这一T-32计划协调了有前途的博士后ACGME常驻候选人的指导，这些候选人将渴望获得学术教职职位，并将加强UAB的特殊指导环境。这项T-32拨款代表了UAB的四个孢子项目之间的教员合作和协同科学利益的机制。在方案上，有效的跨学科研究经验是通过强制性地纳入所需的教学，通过导师和个人研究计划所需的课程工作来实施的。在这次竞争性更新中，统计学和研究伦理方面的课程工作得到了加强，临床和翻译科学中心(CCTS)和博士后教育办公室在教学质量、手稿写作和翻译研究方面提供了正式指导。在过去的五年里，22名ACGME外科和妇科肿瘤学住院实习生得到了这一T-32机制的支持。由于研究生外科培训接近7-10年，而T-32学员在其职业生涯的早期阶段进行研究，相当数量的学员在学术任命之前仍有5年的外科培训剩余时间。因此，经过10年的持续资助，我们的项目才刚刚开始取得学术上的成功。在过去10年中，已有36名学员完成了他们的T-32培训，其中70%的学员继续进行学术生物医学研究和实践/培训。此外，在过去五年中，T-32是性别均衡的，其中17%是代表不足的少数族裔。在过去的十年里，T32为受训者提供了持续的强有力的承诺，监督和鼓励他们对调查和学术界的职业做出互惠的承诺。这反映在那些在外科、肿瘤学和妇产科其他医学院完成学术教职培训的人身上。因此，每年需要为6000名博士后驻地实习生继续提供资金。

DESCRIPTION (provided by applicant): This competitive renewal was originally funded in 2002, and is now completing the fourth year of its second five-year cycle (10th year). This T32 builds upon established clinical and scientific strengths in various oncologic disciplines of the Departments of Surgery and Obstetrics/Gynecology. The partnership of both Departments with UAB Comprehensive Cancer Center provides an integrated infrastructure of collaborative bench science that spans fundamental molecular discovery to move scientific inquiry from bench-to-bedside for applied clinical and translational research. This training environment enhances the intra-collaborative, seamless trans-departmental initiatives available in Tumor Biology and Immunology, Human Genetics, Autoimmunity and Inflammation, Translational Clinical and Outcomes Research. The strategic goals of the research plan have special emphasis on the training of nascent, promising young Surgical-Scientists in their early post-doctoral years and who are in ACGME-approved training programs in Surgery or Gynecologic Oncology. Thus, this T-32 program coordinates the mentorship of promising post- doctoral ACGME resident-candidates who will aspire to academic faculty positions and will strengthen UAB's exceptional mentoring environment. This T-32 grant represents a mechanism for faculty collaboration and synergistic scientific interests among its four SPORE programs at UAB. Programmatically, an effective interdisciplinary research experience is implemented by the obligatory incorporation of the required teaching via mentors and the required course work for individual research plans. Course work in statistics and ethical conduct of research is augmented in this competitive renewal with formal instruction provided by the Center for Clinical and Translational Science (CCTS) and the Office of Post-Doctoral Education in grantsmanship, manuscript writing, and translational research. Over the past five years, 22 ACGME resident-trainees in Surgery and Gynecologic Oncology were supported by this T-32 mechanism. Because post-graduate surgical training approaches 7-10 years, and T-32 Trainees conduct research in the early stages of their career, a significant number of trainees still have >5 years of surgical training remaining prior to academic appointment. Therefore, we are just beginning to see the academic success of our program after 10 years of continuous funding. In the past 10 years, there have been 36 trainees that have completed their T-32 training with 70 % of these residents continuing in academic biomedical research and practice / training. Moreover, in the past five years, this T-32 has been gender-balanced and has included 17% under-represented minorities. This T32 has, over the past ten years, provided continual strong commitment to trainees with oversight and encouragement of reciprocal commitment to careers in investigation and academia. This is reflected by those who have completed training with academic faculty positions in other Schools of Medicine within Departments of Surgery, its oncology disciplines, and Obstetrics/Gynecology. Continued funding is therefore requested annually for 6 post-doctoral resident-trainees.