The Manhattan HIV Brain Bank

描述(由申请人提供)：国家神经艾滋病组织联合会(NNTC)成立于1998年，旨在通过提供神经系统组织和来自艾滋病毒感染者的体液样本来推动神经艾滋病的研究，这些样本在生命中收集了全面的神经医学、神经认知、精神病学和实验室数据。曼哈顿艾滋病毒脑库(MHBB)是NNTC的4个创始成员之一。NNTC收集了1728名参与者的生前数据，并对721名个体进行了尸检，向212名调查人员的请求分发了样本和数据。在保持全面、标准化的数据和组织应计过程以及数据/样本分配的同时，NNTC提出了一项重组计划，以使联盟范围内的科学议程得以发展。设想了三个层次的科学活动：1)利用独特的专业知识，在NNTC地点进行地方初步/可行性研究；2)NNTC范围内的“内部”议程，解决与该联盟庞大、独特的生前和尸检信息收集有关的问题；以及3)为神经艾滋病研究的新方向提供更广泛的领导。MHBB将独一无二地为新的NNTC的所有级别的资源和科学活动做出贡献。我们的群体中有很大比例的非裔美国人和西班牙裔少数族裔，代表了受艾滋病毒/艾滋病影响不成比例的美国人口。我们的女性比例很高，并与女性机构间艾滋病毒研究合作，为评估神经系统疾病的性别相关方面提供了机会。我们已经开始并提议继续进行一系列地方试点分析，以阐明MHBB中的共病和神经艾滋病差异的影响，我们将推进NNTC的共同议程。我们召集了研究人员，他们的专业知识非常适合于制定内部和更广泛的议程，研究差异、并存和周围神经病变。我们已经并将继续通过提供组织样本来支持并继续协助各种神经艾滋病和艾滋病研究人员，并将通过进行基于组织微阵列的免疫组织化学来统一注释NNTC脑收集来提高样本价值。在MHBB的全面参与下，NNTC的新的科学重点和修订的结构将使我们能够贡献并响应关于艾滋病相关神经系统疾病潜在的神经生物学机制的快速发展的知识。 A部分：

DESCRIPTION (provided by applicant): The National NeuroAIDS Tissue Consortium (NNTC) was established in 1998 to advance neuroAIDS research by providing nervous system tissues and fluid samples from persons dying with HIV on whom comprehensive neuromedical, neurocognitive, psychiatric, and laboratory data were gathered during life. The Manhattan HIV Brain Bank (MHBB) is one of 4 founding members of the NNTC. The NNTC has collected antemortem data on 1728 participants and autopsied 721 individuals, distributing samples and data to 212 requests from investigators. While maintaining comprehensive, standardized data and tissue accrual processes and data/sample distribution, the NNTC proposes a restructuring plan to enable development of a consortium-wide scientific agenda. Three levels of scientific activity are envisioned: 1) local preliminary/feasibility studies at NNTC sites, taking advantage of unique expertise; 2) an NNTC-wide "internal" agenda addressing questions with the consortium's large, unique collection of antemortem and postmortem information; and 3) providing broader leadership for new directions in neuroAIDS research. The MHBB will be uniquely poised to contribute to all levels of resource and scientific activity in the new NNTC. Our cohort, with its large percentage of African American and Hispanic minorities, is representative of the US populations disproportionately impacted by HIV/AIDS. Our large percentage of women and collaboration with the Women's Interagency HIV Study offer an opportunity to evaluate gender-related aspects of nervous system disorders. We have begun, and propose to continue, a series of local pilot analyses to elucidate the impact of co-morbidities and neuroAIDS disparities in the MHBB, which we will advance to the shared NNTC agenda. We have assembled investigators whose expertise is well suited to contribute to the development of internal and broader agendas studying disparities, co-morbidities and peripheral neuropathy. We have supported, and will continue to assist, a variety of neuroAIDS and AIDS investigators by providing tissue samples, and will enhance sample value by performing tissue microarray-based immunohistochemistry to uniformly annotate the NNTC brain collection. The new scientific emphasis and revised structure of the NNTC, with full participation of the MHBB, will enable us to contribute, and be responsive, to rapidly evolving knowledge regarding the neurobiological mechanisms underlying AIDS-related nervous system disorders. Part A: