The Manhattan HIV Brain Bank

曼哈顿艾滋病脑库

• 批准号: 7494194
• 负责人: Susan Morgello
• 金额: $ 162.34万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-05 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7494194
• 关键词: AIDS neuropathy; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; African American; Autopsy; Brain; Collaborations; Collection; Data; Development; Feasibility Studies; Gender; HIV; Hispanics; Immunohistochemistry; Individual; Knowledge; Laboratories; Leadership; Life; Liquid substance; Minority; Morbidity - disease rate; Nervous system structure; Neurocognitive; Participant; Peripheral Nervous System Diseases; Personal Satisfaction; Persons; Population; Research; Research Personnel; Resources; Sampling; Series; Site; Structure; Tissue Microarray; Tissue Sample; Tissues; Woman; base; cohort; computerized data processing; member; nervous system disorder; neurobiological mechanism

DESCRIPTION (provided by applicant): The National NeuroAIDS Tissue Consortium (NNTC) was established in 1998 to advance neuroAIDS research by providing nervous system tissues and fluid samples from persons dying with HIV on whom comprehensive neuromedical, neurocognitive, psychiatric, and laboratory data were gathered during life. The Manhattan HIV Brain Bank (MHBB) is one of 4 founding members of the NNTC. The NNTC has collected antemortem data on 1728 participants and autopsied 721 individuals, distributing samples and data to 212 requests from investigators. While maintaining comprehensive, standardized data and tissue accrual processes and data/sample distribution, the NNTC proposes a restructuring plan to enable development of a consortium-wide scientific agenda. Three levels of scientific activity are envisioned: 1) local preliminary/feasibility studies at NNTC sites, taking advantage of unique expertise; 2) an NNTC-wide "internal" agenda addressing questions with the consortium's large, unique collection of antemortem and postmortem information; and 3) providing broader leadership for new directions in neuroAIDS research. The MHBB will be uniquely poised to contribute to all levels of resource and scientific activity in the new NNTC. Our cohort, with its large percentage of African American and Hispanic minorities, is representative of the US populations disproportionately impacted by HIV/AIDS. Our large percentage of women and collaboration with the Women's Interagency HIV Study offer an opportunity to evaluate gender-related aspects of nervous system disorders. We have begun, and propose to continue, a series of local pilot analyses to elucidate the impact of co-morbidities and neuroAIDS disparities in the MHBB, which we will advance to the shared NNTC agenda. We have assembled investigators whose expertise is well suited to contribute to the development of internal and broader agendas studying disparities, co-morbidities and peripheral neuropathy. We have supported, and will continue to assist, a variety of neuroAIDS and AIDS investigators by providing tissue samples, and will enhance sample value by performing tissue microarray-based immunohistochemistry to uniformly annotate the NNTC brain collection. The new scientific emphasis and revised structure of the NNTC, with full participation of the MHBB, will enable us to contribute, and be responsive, to rapidly evolving knowledge regarding the neurobiological mechanisms underlying AIDS-related nervous system disorders. Part A:

描述（由申请人提供）：国家神经艾滋病组织联盟 (NNTC) 成立于 1998 年，旨在通过提供艾滋病毒死亡者的神经系统组织和体液样本来推进神经艾滋病研究，这些人在生前收集了全面的神经医学、神经认知、精神病学和实验室数据。曼哈顿 HIV 脑库 (MHBB) 是 NNTC 的 4 个创始成员之一。 NNTC 收集了 1728 名参与者的生前数据，并对 721 名参与者进行了尸检，并根据调查人员的 212 份请求分发了样本和数据。在维持全面、标准化的数据和组织应计流程以及数据/样本分配的同时，NNTC 提出了一项重组计划，以制定整个联盟范围内的科学议程。设想了三个层次的科学活动：1）利用独特的专业知识，在 NNTC 地点进行当地初步/可行性研究； 2) NNTC 范围内的“内部”议程，解决该联盟大量、独特的事前和事后信息收集的问题； 3）为神经艾滋病研究的新方向提供更广泛的领导。 MHBB 将做好独特准备，为新 NNTC 的各个层面的资源和科学活动做出贡献。我们的群体中有很大一部分是非裔美国人和西班牙裔少数族裔，代表了受艾滋病毒/艾滋病影响尤为严重的美国人口。我们的女性比例很高，并且与女性机构间艾滋病毒研究合作，为评估神经系统疾病的性别相关方面提供了机会。我们已经开始并建议继续进行一系列本地试点分析，以阐明 MHBB 中合并症和神经艾滋病差异的影响，我们将把这些分析推进到共同的 NNTC 议程中。我们聚集了研究人员，他们的专业知识非常适合为研究差异、共病和周围神经病变的内部和更广泛议程的制定做出贡献。我们已经并将继续通过提供组织样本来支持各种神经艾滋病和艾滋病研究人员，并将通过进行基于组织微阵列的免疫组织化学来统一注释 NNTC 大脑集合来提高样本价值。在 MHBB 的全面参与下，NNTC 的新科学重点和修订结构将使我们能够对快速发展的关于艾滋病相关神经系统疾病的神经生物学机制的知识做出贡献并做出反应。 A部分：