The Manhattan HIV Brain Bank

描述（由申请人提供）：国家神经艾滋病组织联盟（NNTC）成立于1998年，旨在通过提供艾滋病患者的神经系统组织和液体样本来推进神经艾滋病研究，这些患者一生中收集了全面的神经医学、神经认知、精神病学和实验室数据。曼哈顿艾滋病毒脑库（MHBB）是NNTC的四个创始成员之一。NNTC收集了1728名参与者的死前数据，并对721人进行了尸检，将样本和数据分发给了调查人员的212份请求。在保持全面、标准化的数据和组织累积过程以及数据/样本分布的同时，NNTC提出了一项重组计划，以便制定整个联盟的科学议程。预计将开展三个层次的科学活动：1)利用独特的专业知识，在NNTC站点进行当地初步/可行性研究；2) nntc范围内的“内部”议程，利用该联盟收集的大量独特的死前和死后信息来解决问题；3)为神经艾滋病研究的新方向提供更广泛的领导。MHBB将以独特的姿态为新的NNTC的各级资源和科学活动作出贡献。我们的队列中有很大比例的非裔美国人和西班牙裔少数民族，是受艾滋病毒/艾滋病不成比例影响的美国人口的代表。我们很大比例的妇女以及与妇女机构间艾滋病毒研究的合作提供了一个评估神经系统疾病与性别相关方面的机会。我们已经开始并建议继续进行一系列的地方试点分析，以阐明MHBB中合并症和神经艾滋病差异的影响，我们将把这些分析推进到NNTC共同议程中。我们汇集了专家，他们的专业知识非常适合为研究差异、合并症和周围神经病变的内部和更广泛议程的发展做出贡献。我们已经并将继续通过提供组织样本来支持各种神经艾滋病和艾滋病研究者，并将通过执行组织微阵列免疫组织化学来统一注释NNTC脑收集来提高样本价值。在MHBB的充分参与下，NNTC新的科学重点和修订的结构将使我们能够对艾滋病相关神经系统疾病的神经生物学机制方面快速发展的知识作出贡献并作出反应。

DESCRIPTION (provided by applicant): The National NeuroAIDS Tissue Consortium (NNTC) was established in 1998 to advance neuroAIDS research by providing nervous system tissues and fluid samples from persons dying with HIV on whom comprehensive neuromedical, neurocognitive, psychiatric, and laboratory data were gathered during life. The Manhattan HIV Brain Bank (MHBB) is one of 4 founding members of the NNTC. The NNTC has collected antemortem data on 1728 participants and autopsied 721 individuals, distributing samples and data to 212 requests from investigators. While maintaining comprehensive, standardized data and tissue accrual processes and data/sample distribution, the NNTC proposes a restructuring plan to enable development of a consortium-wide scientific agenda. Three levels of scientific activity are envisioned: 1) local preliminary/feasibility studies at NNTC sites, taking advantage of unique expertise; 2) an NNTC-wide "internal" agenda addressing questions with the consortium's large, unique collection of antemortem and postmortem information; and 3) providing broader leadership for new directions in neuroAIDS research. The MHBB will be uniquely poised to contribute to all levels of resource and scientific activity in the new NNTC. Our cohort, with its large percentage of African American and Hispanic minorities, is representative of the US populations disproportionately impacted by HIV/AIDS. Our large percentage of women and collaboration with the Women's Interagency HIV Study offer an opportunity to evaluate gender-related aspects of nervous system disorders. We have begun, and propose to continue, a series of local pilot analyses to elucidate the impact of co-morbidities and neuroAIDS disparities in the MHBB, which we will advance to the shared NNTC agenda. We have assembled investigators whose expertise is well suited to contribute to the development of internal and broader agendas studying disparities, co-morbidities and peripheral neuropathy. We have supported, and will continue to assist, a variety of neuroAIDS and AIDS investigators by providing tissue samples, and will enhance sample value by performing tissue microarray-based immunohistochemistry to uniformly annotate the NNTC brain collection. The new scientific emphasis and revised structure of the NNTC, with full participation of the MHBB, will enable us to contribute, and be responsive, to rapidly evolving knowledge regarding the neurobiological mechanisms underlying AIDS-related nervous system disorders. Part A: