The Manhattan HIV Brain Bank

曼哈顿艾滋病脑库

• 批准号: 9059775
• 负责人: Susan Morgello
• 金额: $ 131.36万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9059775
• 关键词: Acquired Immunodeficiency Syndrome; Age; Aging; Assessment tool; Autopsy; Behavioral; Brain; Business Rules; Central Nervous System Diseases; Cessation of life; Characteristics; Client; Clinical; Clinical Data; Cognition Disorders; Collection; Communities; Complex; Data; Data Coordinating Center; Databases; Diagnosis; Dictionary; Disease; Enrollment; Epidemic; Equipment and supply inventories; Future; HIV; HIV-associated neurocognitive disorder; Health; Individual; Infection; Instruction; Investigation; Laboratories; Life; Liquid substance; Logic; Longitudinal Studies; Manuals; Maps; Medical; Methods; Minority; Modification; Neurologic; Neurology; Neuropathogenesis; Neuropsychology; New York City; Nucleic Acids; Observational Study; Organ Donor; Pathogenesis; Pathologic; Pathology; Patients; Peripheral Nervous System Diseases; Phenotype; Plasma; Primary Health Care; Principal Investigator; Process; Protocols documentation; Records; Reporting; Research; Research Design; Research Personnel; Resources; Sampling Errors; Science; Services; Site; Spinal Cord; System; Testing; Therapeutic; Tissues; Viral Load result; Viral reservoir; Viremia; Viscera; Woman; Work; antiretroviral therapy; base; brain tissue; cohort; computerized; high risk; literacy; medical schools; meetings; member; mortality; multidisciplinary; nervous system disorder; neuroAIDS; neuropsychiatry; neuropsychological; prevent; programs; quality assurance; response

DESCRIPTION (provided by applicant): The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), has been a resource for the neuroAIDS research community since 1998. It performs neurologic, neuropsychological, psychiatric, general medical, and autopsy pathology assessments on a cohort of predominantly HIV-infected individuals, who agree to be organ donors upon demise, for the purposes of neuroAIDS and AIDS research. As a result of MHBB's observational longitudinal study, its tissue and fluids resources are densely annotated, and support a wide range of investigations into HIV-associated central (CNS) and peripheral nervous system (PNS) disorders. In the next cycle, MHBB will participate with other members of the NNTC to create a cohort optimized for the study of CNS reservoirs, aging, and pathogenesis of HIV-associated cognitive disorders persisting in the face of antiretroviral therapy. Specifically, MHBB will increase its representatin of older individuals, and those with stably suppressed plasma viral loads following variable CD4 nadirs. With this transition, MHBB will maintain important cohort characteristics reflective of the NYC epidemic, including prominent representation of minorities, women, and socio-culturally and medically complex individuals. MHBB will regularly upload clinical and pathologic information into a central consortium database, participate in all the protocol-defining and qualit assurance programs of the NNTC, and distribute its information, tissues, and fluids to investigators through central processes led by the NNTC data coordination center. MHBB will continue to analyze the behavioral and neurologic phenotypes of its cohort, to better understand how neuroAIDS disorders manifest in aging, demographically diverse individuals living through changes in therapeutic eras. Through observational studies, MHBB will better serve neuroAIDS researchers, as careful delineation of phenotype will assure better assignment of resources to research designs. Furthermore, observational study of HIV-associated CNS and PNS disease will allow MHBB to better understand neurobiologically relevant methods for subject characterization, and how to continue modifications of the cohort as the HIV epidemic continues to evolve.

描述（由申请人提供）：曼哈顿 HIV 脑库 (MHBB) 是国家神经艾滋病组织联盟 (NNTC) 的成员，自 1998 年以来一直是神经艾滋病研究界的资源。它对一群主要感染艾滋病毒的个体进行神经病学、神经心理学、精神病学、一般医学和尸检病理学评估，这些个体同意成为器官捐献者 死亡，用于神经艾滋病和艾滋病研究的目的。 MHBB 的观察性纵向研究的结果是，其组织和液体资源得到了密集注释，并支持对 HIV 相关中枢 (CNS) 和周围神经系统 (PNS) 疾病的广泛研究。在下一个周期中，MHBB 将与 NNTC 的其他成员一起创建一个针对 CNS 储存库、衰老以及抗逆转录病毒治疗中持续存在的 HIV 相关认知障碍的发病机制的研究而优化的队列。具体来说，MHBB 将增加老年人的代表性，以及那些在 CD4 最低点后血浆病毒载量稳定受到抑制的人。通过这一转变，MHBB 将保持重要的队列特征，反映 纽约市的流行病，包括少数族裔、妇女以及社会文化和医学复杂的个人的突出代表。 MHBB 将定期将临床和病理信息上传到中央联盟数据库，参与 NNTC 的所有协议定义和质量保证计划，并通过 NNTC 数据协调中心领导的中央流程将其信息、组织和液体分发给研究人员。 MHBB 将继续分析其队列的行为和神经表型，以更好地了解神经艾滋病疾病如何在经历治疗时代变化的老龄化、人口多样化的个体中表现出来。通过观察性研究，MHBB 将更好地为神经艾滋病研究人员服务，因为仔细描述表型将确保更好地将资源分配给研究设计。此外，对 HIV 相关中枢神经系统和三七总皂甙疾病的观察性研究将使 MHBB 更好地了解用于受试者表征的神经生物学相关方法，以及如何随着 HIV 流行的不断发展而继续修改队列。