The Manhattan HIV Brain Bank

项目总结 曼哈顿艾滋病毒脑库(MHBB)是国家神经艾滋病组织联盟(NNTC)的成员，是一家 致力于为科学家提供注释密集、高质量的生物标本的研究资源 支持神经艾滋病和艾滋病研究。位于纽约市，它进行纵向的，观察性的 神经学、神经心理学和精神病学研究，对象为同意捐献器官的个人 死亡。在与NNTC其他成员协调其评估和活动的同时，MHBB保留 重要而独特的特点。MHBB是一个以少数族裔为主的群体，具有出色的代表性 服务不足的人群，包括非洲裔美国人和加勒比裔拉美人；大约一半 MHBB参与者是女性；总体人口表现出较高的医疗和 导致神经系统功能障碍的心理社会共病。队列中也有优秀的 代表长期抑制病毒的个人，适合支持病毒研究 水库。在提供其生物样本和数据资源方面，MHBB实施了标准的NNTC协议以 将提供给研究人员的材料的类型和质量与其他NNTC临床站点同步。然而， MHBB还创建了各种定制资源，以更好地为客户服务，包括提供 数字幻灯片和查看软件，以加强病例选择和分析；从以下地点获取新鲜血液样本 功能分析的队列，当与MHBB广泛的神经系统特征相结合时， 提供具有成本效益的机制来完成翻译性神经艾滋病研究； 专门的组织解剖，以创建独特的集合，如大脑动脉重塑研究。MHBB是 致力于培养从事神经艾滋病研究事业的年轻科学家，并在过去的 R25机制，并计划在下一个供资期间利用其资源推广F-型和K型奖励。 MHBB通过成熟的数据库辅助协议，对其收集的信息保持高质量标准 为保证地方一级的质量，使用NNTC提供的月度数据报告和年度审计 协调中心，并参与所有NNTC小组委员会，以确保遵守标准化 NNTC评估。凭借相对较少和敬业的员工，MHBB能够迅速适应NNTC 倡议，因为其组织结构和标准的运作程序导致频繁的沟通 各专业水平和领域之间的联系。此外，MHBB利用MHBB的人才和扩展的专业知识 它的科学顾问和多个合作者，他们提供了一个强大的翻译科学环境 加强研究的可操作性。 5.

PROJECT SUMMARY The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), is a research resource committed to providing scientists with densely annotated, high quality biospecimens in support of neuroAIDS and AIDS research. Located in New York City, it conducts a longitudinal, observational neurologic, neuropsychologic, and psychiatric study with individuals who agree to be organ donors upon demise. While harmonizing its assessments and activities with other members of the NNTC, MHBB retains important and unique characteristics. MHBB is a predominantly minority cohort with excellent representation of underserved populations, including African Americans and Latinos of Caribbean origin; approximately half of MHBB participants are women; and the population overall displays a high frequency of medical and psychosocial co-morbidities that contribute to nervous system dysfunction. The cohort also has excellent representation of individuals with long-term viral suppression, suited to the support of research into viral reservoirs. In providing its biospecimen and data resources, MHBB implements standard NNTC protocols to synchronize the type and quality of materials provided to researchers with other NNTC clinical sites. However, MHBB has also created a variety of customized resources to better serve its clients, inclusive of providing digital slides and viewing software to enhance case selection and analysis; obtaining fresh blood samples from the cohort for functional assays, which when coupled with MHBB's extensive nervous system characterization, provide a cost efficient mechanism to accomplish translational neuroAIDS research; and performing specialized tissue dissections to create unique collections like the Brain Arterial Remodeling Study. MHBB is committed to fostering young scientists embarking on careers in neuroAIDS research, with past support of an R25 mechanism, and plans to promote F- and K- type awards utilizing its resources in the next funding period. MHBB maintains high quality standards for the information it collects, with mature, databank-assisted protocols for quality assurance on the local level, use of monthly data reports and annual audits provided by the NNTC coordinating center, and participation in all NNTC subcommittees to assure compliance with standardized NNTC assessments. With a relatively small and dedicated staff, MHBB is able to rapidly adapt to NNTC initiatives, as its organizational structure and standard operating procedures result in frequent communication between all levels and domains of expertise. In addition, MHBB utilizes the talents and expanded expertise of its scientific advisor and multiple collaborators, who provide a robust translational science environment to enhance the study's operations. 5