The Manhattan HIV Brain Bank

曼哈顿艾滋病脑库

• 批准号: 10818199
• 负责人: Susan Morgello
• 金额: $ 35.96万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818199
• 关键词: Acquired Immunodeficiency Syndrome; Activities of Daily Living; African American population; Aging; Agreement; Assessment tool; Autopsy; Award; Back; Biological Assay; Blood specimen; Brain; Brain Death; Caribbean region; Characteristics; Client; Clinical; Clinical Data; Collection; Communication; Computer software; Consultations; Contracts; Coupled; Data; Data Coordinating Center; Data Reporting; Dedications; Diagnosis; Disease; Dissection; Education Projects; Environment; Epidemic; Equipment and supply inventories; Feedback; Fostering; Frequencies; Functional disorder; Funding; Goals; HIV; Individual; Interview; Latino Population; Liquid substance; Longevity; Longitudinal, observational study; Mediation; Medical; Mentors; Minority; National NeuroAids Tissue Consortium; Nervous System; Neurologic; Neurological observations; Neuropsychology; New York City; Nucleic Acids; Organ; Organ Donations; Organ Donor; Participant; Pathogenesis; Pathology; Patients; Personal Satisfaction; Persons; Plasma; Population; Procedures; Protocols documentation; Qualifying; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Science; Scientist; Serum; Services; Slide; Specimen; Spinal Cord; Standardization; Strategic Planning; Talents; Testing; Tissue Harvesting; Tissues; Training; Translational Research; Underserved Population; United States National Institutes of Health; Urine; Validation; Viral; Viral reservoir; Viscera; Woman; Work; antiretroviral therapy; arterial remodeling; biobank; career; clinical research site; cohort; comorbidity; cost efficient; cultural competence; data repository; data resource; digital; flexibility; improved; informal caregiver; medical schools; meetings; member; nervous system disorder; neuroAIDS; novel; operation; organizational structure; primary care provider; psychosocial; quality assurance; recruit; response; social culture; transmission process

PROJECT SUMMARY The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), is a research resource committed to providing scientists with densely annotated, high quality biospecimens in support of neuroAIDS and AIDS research. Located in New York City, it conducts a longitudinal, observational neurologic, neuropsychologic, and psychiatric study with individuals who agree to be organ donors upon demise. While harmonizing its assessments and activities with other members of the NNTC, MHBB retains important and unique characteristics. MHBB is a predominantly minority cohort with excellent representation of underserved populations, including African Americans and Latinos of Caribbean origin; approximately half of MHBB participants are women; and the population overall displays a high frequency of medical and psychosocial co-morbidities that contribute to nervous system dysfunction. The cohort also has excellent representation of individuals with long-term viral suppression, suited to the support of research into viral reservoirs. In providing its biospecimen and data resources, MHBB implements standard NNTC protocols to synchronize the type and quality of materials provided to researchers with other NNTC clinical sites. However, MHBB has also created a variety of customized resources to better serve its clients, inclusive of providing digital slides and viewing software to enhance case selection and analysis; obtaining fresh blood samples from the cohort for functional assays, which when coupled with MHBB's extensive nervous system characterization, provide a cost efficient mechanism to accomplish translational neuroAIDS research; and performing specialized tissue dissections to create unique collections like the Brain Arterial Remodeling Study. MHBB is committed to fostering young scientists embarking on careers in neuroAIDS research, with past support of an R25 mechanism, and plans to promote F- and K- type awards utilizing its resources in the next funding period. MHBB maintains high quality standards for the information it collects, with mature, databank-assisted protocols for quality assurance on the local level, use of monthly data reports and annual audits provided by the NNTC coordinating center, and participation in all NNTC subcommittees to assure compliance with standardized NNTC assessments. With a relatively small and dedicated staff, MHBB is able to rapidly adapt to NNTC initiatives, as its organizational structure and standard operating procedures result in frequent communication between all levels and domains of expertise. In addition, MHBB utilizes the talents and expanded expertise of its scientific advisor and multiple collaborators, who provide a robust translational science environment to enhance the study's operations. 5

项目摘要 曼哈顿艾滋病毒脑库（MHBB）是国家神经艾滋病组织联盟（NNTC）的成员，是一个 致力于为科学家提供密集注释的高质量生物标本的研究资源， 支持神经艾滋病和艾滋病研究。它位于纽约市， 对同意成为器官捐献者的个人进行神经学、神经心理学和精神病学研究， 死亡在与国家核技术委员会其他成员协调其评估和活动的同时， 重要而独特的特征。MHBB是一个主要的少数群体， 服务不足的人口，包括非洲裔美国人和加勒比裔拉丁美洲人; MHBB参与者是女性;总体人口显示出较高的医疗和 导致神经系统功能障碍的心理社会共病。该队列还具有出色的 代表长期病毒抑制的个人，适合支持病毒研究 水库在提供生物样本和数据资源时，MHBB实施标准NNTC协议， 使提供给研究人员的材料的类型和质量与其他NNTC临床研究中心同步。然而，在这方面， MHBB还创建了各种定制资源，以更好地为客户服务，包括提供 数字幻灯片和查看软件，以加强病例选择和分析;从 用于功能测定的队列，当与MHBB的广泛神经系统表征相结合时， 提供一个具有成本效益的机制，以完成转化神经艾滋病研究;并执行 专门的组织解剖，创造独特的收藏，如脑动脉重塑研究。MHBB是 致力于培养年轻科学家从事神经艾滋病研究的职业生涯，过去曾得到一个 R25机制，并计划在下一个资助期内利用其资源促进F和K类奖励。 MHBB通过成熟的数据库辅助协议，对所收集的信息保持高质量标准 对于地方一级的质量保证，使用NNTC提供的月度数据报告和年度审计 协调中心，并参与所有NNTC小组委员会，以确保遵守标准化 NNTC评估。MHBB拥有相对较少的专职员工，能够快速适应NNTC 由于其组织结构和标准作业程序， 在各个层次和领域的专业知识。此外，MHBB利用的人才和扩大的专业知识， 它的科学顾问和多个合作者，他们提供了一个强大的转化科学环境， 加强研究工作。 5

项目成果

HIV disease duration, but not active brain infection, predicts cortical amyloid beta deposition.

• DOI: 10.1097/qad.0000000000002893
• 发表时间: 2021-07-15
• 期刊: AIDS (London, England)
• 作者: Morgello S;Cortes EP;Gensler G;Meloni G;Jacobs MM;Murray J;Borukov V;Crary JF
• 通讯作者: Crary JF

Alzheimer's disease neuropathology may not predict functional impairment in HIV: a report of two individuals.

• DOI: 10.1007/s13365-018-0663-z
• 发表时间: 2018-10
• 期刊: Journal of neurovirology
• 影响因子: 3.2
• 作者: Morgello S;Jacobs M;Murray J;Byrd D;Neibart E;Mintz L;Meloni G;Chon C;Crary J
• 通讯作者: Crary J

Effects of information processing speed on learning, memory, and executive functioning in people living with HIV/AIDS.

• DOI: 10.1080/13803395.2014.943696
• 发表时间: 2014
• 期刊: Journal of clinical and experimental neuropsychology
• 影响因子: 2.2
• 作者: Fellows RP;Byrd DA;Morgello S
• 通讯作者: Morgello S

Expression of ephrin receptors and ligands in postmortem brains of HIV-infected subjects with and without cognitive impairment.

有或没有认知障碍的 HIV 感染者死后大脑中肝配蛋白受体和配体的表达

• DOI: 10.1007/s11481-012-9429-1
• 发表时间: 2013-03
• 期刊: JOURNAL OF NEUROIMMUNE PHARMACOLOGY
• 影响因子: 6.2
• 作者: Yuferov, Vadim;Ho, Ann;Morgello, Susan;Yang, Yaning;Ott, Jurg;Kreek, Mary Jeanne
• 通讯作者: Kreek, Mary Jeanne

Depressive Symptoms Differentially Predict Neurocognition in Latinx and Non-Hispanic White People Living with HIV.

• DOI: 10.1017/s1355617720000855
• 发表时间: 2021-03
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Morris EP;Byrd D;Summers AC;Tureson K;Guzman V;Crook CL;Rivera Mindt M
• 通讯作者: Rivera Mindt M