The Manhattan HIV Brain Bank

曼哈顿艾滋病脑库

• 批准号: 8539921
• 负责人: Susan Morgello
• 金额: $ 131.36万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8539921
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Age; Aging; Autopsy; Behavioral; Brain; Business Rules; Central Nervous System Diseases; Cessation of life; Characteristics; Client; Clinical; Clinical Data; Cognition Disorders; Collection; Communities; Complex; Data; Data Coordinating Center; Databases; Diagnosis; Dictionary; Disease; Enrollment; Epidemic; Equipment and supply inventories; Future; HIV; Individual; Infection; Instruction; Investigation; Laboratories; Life; Liquid substance; Logic; Longitudinal Studies; Manuals; Maps; Medical; Methods; Minority; Modification; Neurocognitive; Neurologic; Neurology; Neuropathogenesis; Neuropsychology; New York City; Nucleic Acids; Observational Study; Organ Donor; Pathogenesis; Pathologic; Pathology; Patients; Peripheral Nervous System Diseases; Phenotype; Plasma; Primary Health Care; Principal Investigator; Process; Protocols documentation; Records; Reporting; Research; Research Design; Research Personnel; Resources; Sampling Errors; Science; Services; Site; Spinal Cord; System; Testing; Therapeutic; Tissues; Viral; Viral Load result; Viremia; Viscera; Woman; Work; antiretroviral therapy; base; brain tissue; cohort; computerized; high risk; literacy; medical schools; meetings; member; mortality; multidisciplinary; nervous system disorder; neuropsychiatry; neuropsychological; prevent; programs; public health relevance; quality assurance; response; tool

DESCRIPTION (provided by applicant): The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), has been a resource for the neuroAIDS research community since 1998. It performs neurologic, neuropsychological, psychiatric, general medical, and autopsy pathology assessments on a cohort of predominantly HIV-infected individuals, who agree to be organ donors upon demise, for the purposes of neuroAIDS and AIDS research. As a result of MHBB's observational longitudinal study, its tissue and fluids resources are densely annotated, and support a wide range of investigations into HIV-associated central (CNS) and peripheral nervous system (PNS) disorders. In the next cycle, MHBB will participate with other members of the NNTC to create a cohort optimized for the study of CNS reservoirs, aging, and pathogenesis of HIV-associated cognitive disorders persisting in the face of antiretroviral therapy. Specifically, MHBB will increase its representatin of older individuals, and those with stably suppressed plasma viral loads following variable CD4 nadirs. With this transition, MHBB will maintain important cohort characteristics reflective of the NYC epidemic, including prominent representation of minorities, women, and socio-culturally and medically complex individuals. MHBB will regularly upload clinical and pathologic information into a central consortium database, participate in all the protocol-defining and qualit assurance programs of the NNTC, and distribute its information, tissues, and fluids to investigators through central processes led by the NNTC data coordination center. MHBB will continue to analyze the behavioral and neurologic phenotypes of its cohort, to better understand how neuroAIDS disorders manifest in aging, demographically diverse individuals living through changes in therapeutic eras. Through observational studies, MHBB will better serve neuroAIDS researchers, as careful delineation of phenotype will assure better assignment of resources to research designs. Furthermore, observational study of HIV-associated CNS and PNS disease will allow MHBB to better understand neurobiologically relevant methods for subject characterization, and how to continue modifications of the cohort as the HIV epidemic continues to evolve.

描述(由申请人提供)：曼哈顿艾滋病毒脑库(MHBB)，国家神经艾滋病组织联盟(NNTC)的成员，自1998年以来一直是神经艾滋病研究社区的资源。它对一群主要感染艾滋病毒的人进行神经学、神经心理学、精神病学、普通医学和尸检病理评估，这些人同意在死亡后成为器官捐赠者，用于神经艾滋病和艾滋病研究。作为MHBB观察性纵向研究的结果，其组织和体液资源被密集地注释，并支持对HIV相关中枢(CNS)和外周神经系统(PNS)疾病的广泛调查。在下一个周期中，MHBB将与NNTC的其他成员一起创建一个队列，以优化CNS储备库、衰老和面对抗逆转录病毒治疗持续存在的艾滋病毒相关认知障碍的发病机制的研究。具体地说，MHBB将增加其在老年个体和那些血浆病毒载量在可变的CD4值之后稳定抑制的个体中的代表性。随着这一过渡，MHBB将保持反映 纽约市流行病，包括少数族裔、妇女以及社会文化和医学上复杂的个人的突出代表。MHBB将定期将临床和病理信息上传到中央联盟数据库，参与NNTC的所有方案定义和质量保证计划，并通过NNTC数据协调中心领导的中央程序将其信息、组织和液体分发给研究人员。MHBB将继续分析其队列的行为和神经学表型，以更好地了解神经艾滋病疾病如何在老年、人口统计多样化的个人中表现出来，这些人生活在治疗时代的变化中。通过观察性研究，MHBB将更好地服务于神经艾滋病研究人员，因为仔细描述表型将确保更好地分配资源用于研究设计。此外，对艾滋病毒相关的CNS和PNS疾病的观察性研究将使MHBB能够更好地了解用于确定受试者特征的神经生物学相关方法，以及如何随着艾滋病毒流行的继续演变而继续修改队列。