Application to host a visiting researcher to collaborate on biocompatible adsorbents for blood purification

申请接待访问研究人员以合作开发用于血液净化的生物相容性吸附剂

• 批准号: EP/D033837/1
• 负责人: Danish Malik
• 金额: $ 2.19万
• 依托单位: Loughborough University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD033837%2F1
• 关键词: Application; host; visiting; researcher; collaborate

The principal aim of the research proposal is to develop effective and biocompatible low cost adsorbents for blood purification. Insight into the relationship between the carbon microstructure on the removal of middle molecules (uraemic toxins) and the influence of the carbon's surface chemistry on the interaction of larger blood proteins (influencing the material's biocompatibility) will result in the development of effective and more economic adsorbents for blood purification. The research seeks to minimize any adverse inflammatory responses upon contact between the carbon adsorbent surface and blood. This will lead not only to new knowledge but also to new and better treatment therapies of direct benefit to patients suffering from renal and liver failure, sepsis and other clinical conditions.

该研究计划的主要目的是开发高效、生物相容的低成本血液净化吸附剂。深入了解碳的微观结构对去除中分子(尿毒症毒素)的影响以及碳的表面化学对大分子血液蛋白相互作用的影响(影响材料的生物相容性)，将有助于开发有效和更经济的血液净化吸附剂。这项研究试图将碳吸附剂表面与血液接触时的任何不良炎症反应降至最低。这不仅将带来新的知识，还将带来新的、更好的治疗方法，直接受益于患有肾功能衰竭、肝功能衰竭、败血症和其他临床疾病的患者。

项目成果

Nanostructured synthetic carbons obtained by pyrolysis of spherical acrylonitrile/divinylbenzene copolymers.

• DOI: 10.1371/journal.pone.0043354
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Malik DJ;Trochimczuk AW;Ronka S
• 通讯作者: Ronka S

Synthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification

• DOI: 10.1016/j.seppur.2009.01.016
• 发表时间: 2009-05-07
• 期刊: SEPARATION AND PURIFICATION TECHNOLOGY
• 影响因子: 8.6
• 作者: Malik, D. J.;Webb, C.;Hoenich, N. A.
• 通讯作者: Hoenich, N. A.