High-Speed Optical Imaging for Medical Diagnosis and Therapy

用于医学诊断和治疗的高速光学成像

• 批准号: 7213018
• 负责人: Oliver D Kripfgans
• 金额: $ 49.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7213018
• 关键词: Back; Biological; Biomedical Engineering; Biomedical Research; Devices; Diagnosis; Diagnostic Procedure; Ensure; Event; Funding; Grant; Guidelines; Image; Individual; Lasers; Life; Low-Level Laser Therapy; Measures; Medical; Monitor; Motion; Optics; Radiology Specialty; Rate; Regulation; Research Personnel; Safety; Speed; System; Therapeutic Uses; Time; Tissues; Training; Ultrasonography; United States National Institutes of Health; digital imaging; human tissue; improved; medical examination; member; nanosecond; optical imaging; particle; response; size

DESCRIPTION (provided by applicant): The objective of this proposal is to acquire a high-speed digital imaging system for use in biomedical research. This system is capable of recording up to 16 images at a rate of up to 200 million frames per second, i.e. 5 nano seconds exposure and back to back framing. A special mode, called streak mode, can be used to record single image lines with a speed of up to 2 billion lines per second. A group of 8 investigators in the Departments of Radiology and Biomedical Engineering was formed. The members of this group are individually funded by R01 and R21/33 type NIH grants. All projects are investigating the general field of micrometer sized bubbles and droplets dynamics, either for individual particles or for clouds, as well as tissue response to ultrasound or focused laser exposure. Some projects are immediately interrelated and all of them will ultimately help to either provide a better understanding for the mechanisms of ultrasound or laser therapy or actually enable therapy. Immediate use of the camera system will be for monitoring the formation of particles in acoustical and optical fields as well as their deformation and motion (also for tissue) due to acoustical and optical forces. Moreover, biological damage resulting from particle dynamics will be measured and evaluated for therapeutic use or to determine safety guidelines/regulations for diagnostic procedures. A committee was formed and guidelines were established by which the camera system can be used and shared among the members of this group and by which new users can gain access to and training for the device. This is to ensure best possible use of the system and maximum contribution for the listed projects and to continuously identify other NIH projects that will benefit from this device. The proposed video camera system can provide images of events that are very short lived (200 million images per second). Medical examinations using ultrasound or laser interact with the human tissue on a time scale that is also very small. This camera is able to record images of these examinations and help us to better understand how to improve diagnosis and treatment.

描述（由申请人提供）：本提案的目标是获得用于生物医学研究的高速数字成像系统。该系统能够以每秒2亿帧的速度记录多达16张图像，即5纳秒曝光和背靠背取景。一种特殊的模式，称为条纹模式，可用于记录单线图像，速度高达每秒20亿行。一个由放射学和生物医学工程系8人组成的研究小组成立了。本小组成员分别由R01和R21/33型NIH拨款资助。所有的项目都在研究微米大小的气泡和液滴动力学的一般领域，无论是单个粒子还是云，以及组织对超声波或聚焦激光照射的反应。有些项目是直接相关的，所有这些项目最终都将有助于更好地理解超声波或激光治疗的机制，或者实际上使治疗成为可能。摄像机系统的直接使用将用于监测声学和光学场中粒子的形成以及它们由于声学和光学力而产生的变形和运动（也用于组织）。此外，将测量和评估由粒子动力学引起的生物损伤，以用于治疗用途或确定诊断程序的安全指南/法规。成立了一个委员会，并制定了指导方针，根据该委员会的成员可以使用和共享相机系统，新用户可以获得该设备的访问和培训。这是为了确保系统的最佳使用和对所列项目的最大贡献，并不断确定将从该设备中受益的其他NIH项目。所提出的视频摄像机系统可以提供非常短的事件图像（每秒2亿个图像）。医学检查使用超声波或激光与人体组织相互作用的时间尺度也非常小。这台摄像机能够记录这些检查的图像，帮助我们更好地了解如何改进诊断和治疗。