AIP1 AND P9 PEPTIDE

AIP1 和 P9 肽

• 批准号: 7358916
• 负责人: CHRISTOPHER P. HILL
• 金额: $ 1.16万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7358916
• 关键词: AIP1; P9; PEPTIDE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research focuses on studying how HIV buds from cells by utilizing cellular machinery normally used in the formation of luminal vesicles of late endosomes. Several proteins in this pathway are required for the budding of several retroviruses, including HIV. One protein in this pathway is AIP1, which binds directly to both HIV and EIAV through a PPXY late domain found in the virus. It is also believed that AIP1 plays an important role in membrane bending events since AIP1 binds to specific lipids found in the late endosome, in addition to binding to proteins which are also believed to function in membrane bending. Structural information on AIP1 and its binding partners will provide insight into how AIP1 binds viruses and how AIP1 could function in bending membranes, both of which are critical for viruses to properly bud from the cell.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们的研究重点是研究艾滋病毒如何从细胞芽，利用细胞机械通常用于形成腔囊泡的晚期内体。这一途径中的几种蛋白质是包括HIV在内的几种逆转录病毒出芽所必需的。该途径中的一种蛋白质是AIP 1，它通过病毒中发现的PPXY晚期结构域直接与HIV和EIAV结合。还认为AIP 1在膜弯曲事件中起重要作用，因为AIP 1除了结合也被认为在膜弯曲中起作用的蛋白质之外，还结合晚期内体中发现的特异性脂质。AIP 1及其结合伴侣的结构信息将提供AIP 1如何结合病毒以及AIP 1如何在弯曲膜中发挥作用的见解，这两者对于病毒从细胞中正确出芽至关重要。