STRUCTURES OF PROTEINS

蛋白质的结构

• 批准号: 8170068
• 负责人: CHRISTOPHER P. HILL
• 金额: $ 0.59万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170068
• 关键词: Capsid; Complex; Computer Retrieval of Information on Scientific Projects Database; Data Collection; Funding; Future; Gagging; Grant; HIV Budding; HIV-1; Institution; Investigation; Maps; Multienzyme Complexes; Nucleosomes; Phase; Protein Subunits; Radiation; Research; Research Personnel; Resolution; Resources; Source; Structure; Time; United States National Institutes of Health; Viral; drug development; heme biosynthesis; multicatalytic endopeptidase complex; protein complex; protein structure; synchrotron radiation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple structures that require synchrotron radiation are currently under investigation. These include 1.1 and 1.2 MDa complexes of up to 42 protein subunits (proteasome activator complexes), structures of HIV-1 Gag-derived domains that are important for viral capsid assembly and dynamics, cellular proteins and complexes that function in HIV budding, nucleosome remodeling and reorganizing complexes, and enzymes of heme biosynthesis. In many cases crystals are currently ready for data collection while in other cases crystals are likely to be obtained within the next few months/years. In some cases we need synchrotron radiation because the diffraction is inherently weak or because crystals are small. Other times we need high resolution to reliability see details of complexes that might guide future effort at drug development. Other times we need tunable radiation in order to obtain phase information or to localize anomalous scattering centers in difference maps.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目前正在研究需要同步辐射的多个结构。 其中包括多达42个蛋白质亚基（蛋白酶体活化剂络合物）的1.1和1.2 MDA复合物，HIV-1 GAG衍生的结构域的结构，这些结构对于病毒capsID组装和动力学，细胞蛋白质和动力学，在HIV萌芽中起作用，核糖体重塑和重新组织复合物和重建Heme and enzysens和Heme nemen的蛋白质和复合物。 在许多情况下，晶体目前已准备好进行数据收集，而在其他情况下，晶体可能会在未来几个月/年内获得。 在某些情况下，我们需要同步辐射，因为衍射本质上是弱或晶体很小的。 在其他时候，我们需要高分辨率对可靠性，请参阅可能指导未来在药物开发方面努力的复合物的细节。 其他时候，我们需要可调辐射才能获得相位信息或将异常散射中心定位在差图中。