An Integrated, Single Pass Analysis Chip for Ionic Liquids

用于离子液体的集成单通道分析芯片

• 批准号: EP/D038294/1
• 负责人: Christopher Hardacre
• 金额: $ 18.2万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD038294%2F1
• 关键词: Integrated; Single; Pass; Analysis; Chip

Over the past decade, ionic liquids have been developed as alternative, environment friendly, solvents. The drive towards cleaner industrial processes has led to the emergence of ionic liquids as potentially preferable solvents for a range of reactions, previously considered harmful and have shown promise in, for example, clean synthesis, electrochemistry, and liquid crystals. Unfortunately, with a few exceptions, ionic liquids have yet to prove their full-scale viability. This is due in large part to the fact that almost all of the available research has focussed on the chemistry rather than developing the data necessary to allow good engineering. However, it has been established that the wide diversity of physical properties that are available in ionic liquid solvents, coupled with their low vapour pressures, give them the potential to be the engineering solvent of choice. These factors also allow the possibility of having the solvent property/structure as a design variable that may be systematically changed to allow optimal performance of the entire process. This would enable plants to be designed without being limited by the solvent used. Despite the enormous potential of this designer solvent approach to optimising reactions, only a handful of ionic liquids are commonly used in current investigations. One of the major reasons is the limited amount of physical property data available as a function of chemical composition. This information is time consuming to collect and requires, for the many measurements necessary, extremely expensive, decilitre quantities of ionic liquid whose purity and exact provenance is known. If ionic liquids are be tailored to meet the needs of a specific process, the physical property database needs to be expanded substantially to include both thermal effects and the variation with added secondary solvent (either another ionic liquid, water or an organic material). In particular, the amount of material necessary for a complete physical property analysis needs to be brought down by about two to three orders of magnitude so that the costs of obtaining the data become negligible. The objective of this proposal is to harness high-throughput, lab-on-a-chip techniques working on very small samples to enable the rapid determination of property variation across a very large composition and temperature space.We believe that the simple availability of such data would serve massively to decrease the reservations regarding the use of ionic liquids in industry by the process engineers and chemists.

在过去的十年中，离子液体已经被开发为替代的、环境友好的溶剂。对清洁工业过程的驱动已经导致离子液体作为一系列反应的潜在优选溶剂的出现，这些反应以前被认为是有害的，并且已经在例如清洁合成、电化学和液晶中显示出前景。不幸的是，除了少数例外，离子液体尚未证明其全面的可行性。这在很大程度上是由于几乎所有可用的研究都集中在化学上，而不是开发必要的数据来进行良好的工程。然而，已经确定的是，离子液体溶剂中可用的广泛多样的物理性质，加上它们的低蒸气压，使它们有可能成为工程溶剂的选择。这些因素还允许具有溶剂性质/结构作为设计变量的可能性，其可以系统地改变以允许整个方法的最佳性能。这将使工厂的设计不受所用溶剂的限制。尽管这种设计溶剂方法在优化反应方面具有巨大的潜力，但目前只有少数离子液体常用于研究。主要原因之一是作为化学成分函数的物理性质数据有限。收集该信息是耗时的，并且对于许多必要的测量，需要极其昂贵的十升量的离子液体，其纯度和确切来源是已知的。如果离子液体被定制以满足特定工艺的需要，则物理性质数据库需要基本上扩展以包括热效应和随添加的第二溶剂（另一种离子液体、水或有机材料）的变化。特别是，需要将完整的物理特性分析所需的材料量减少约两到三个数量级，以便获得数据的成本变得可以忽略不计。这项建议的目的是利用高通量，芯片实验室技术，工作在非常小的样品，使快速确定的性质变化在一个非常大的组成和温度space.We相信，简单的可用性，这样的数据将有助于大量减少使用离子液体在工业中的工艺工程师和化学家的保留。

项目成果

Thermal conductivity measurement of liquids in a microfluidic device

• DOI: 10.1007/s10404-010-0652-x
• 发表时间: 2011
• 期刊: Microfluidics and Nanofluidics
• 影响因子: 2.8
• 作者: D. Kuvshinov;M. Bown;J. Macinnes;R. Allen;R. Ge;L. Aldous;C. Hardacre;N. Doy;M. Newton;G. McHale