CARDIOVASCULAR MODELS & MICRO GRAVITY INDUCED ORTHOSTATIC INTOLERANCE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。航天飞行后直立性不耐受（OI）是与航天飞行相关的最高心血管风险之一。尽管在过去的30多年里做出了相当大的努力，但关于航天后成骨不全的机制仍然缺乏普遍的共识。该项目与美国国家航空航天局合作，旨在检索、存档和分析宇航员在太空飞行前后的倾斜和站立测试数据，并将这些数据与心血管系统的计算模型结合使用，以估计受微重力影响的系统参数。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Post-spaceflight orthostatic intolerance (OI) is one of the highest cardiovascular risks associated with spaceflight. Despite considerable efforts over the past 30+ years, there remains a lack of universal consensus regarding the mechanisms underlying post-spaceflight OI. This project, in conjunction with NASA, aims at retrieving, archiving, and analyzing tilt and stand test data from astronauts pre- and post-spaceflight and using these data in conjunction with computational models of the cardiovascular system to estimate parameters of the system that are affected by exposure to microgravity.