ARCHIVING DATA FROM IMPLANTABLE CARDIOVERTER DEFIBRILLATORS

归档来自植入式心脏复律除颤器的数据

• 批准号: 7366511
• 负责人: ROGER GREENWOOD MARK
• 金额: $ 0.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7366511
• 关键词: ARCHIVING; DATA; IMPLANTABLE; CARDIOVERTER; DEFIBRILLATORS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Researchers have found that the death rate in selected high-risk cardiac patients can be sharply reduced with implantable cardioveter defibrillators (ICDs). The current use of ICDs is the outgrowth of basic biomedical research. The NIH-sponsored TOVA (Triggers of Ventricular Arrhythmias) project is a multi-center study for investigating the trigger causes of life-threatening arrhythmias and for evaluating the effectiveness of existing ICDs. It is aimed at strengthening basic biomedical and clinical research. 2000 patients with ICDs are expected to be entered in the study. Electrogram (EGM) and related data interrogated from ICDs have been stored on floppy disks, in proprietary data format that vary widely with the device manufacturer. Currently clinicians and researchers must use different programming devices to plot the data on paper in order to view and analyze them. For this project we are developing customized software for creating an automated, web-based, and searchable ICD EGM and related data archiving system for the TOVA study. This data archiving system allows investigators to remotely upload ICD interrogation data via the Internet. Data from various ICD models of various manufacturers are automatically converted into a standard public format and are inserted into a database system. Researchers can view and download all the EGM waveforms, annotations, and device setting parameters via the web. Investigators can also make notes on any EGM episodes and can search for specific patients or EGM episodes with specified criteria. This new database system is a critical contribution to the TOVA project, greatly accelerating what has been an unsatisfactory method of collecting, organizing and analyzing data. The system also has the potential to accelerate other important research projects that are based on the investigation of the EGM features associated with life-threatening ventricular arrhythmias.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。研究人员发现，使用植入式心脏复律除颤器 (ICD) 可以大幅降低特定高危心脏病患者的死亡率。目前 ICD 的使用是基础生物医学研究的产物。 NIH 资助的 TOVA（室性心律失常触发因素）项目是一项多中心研究，旨在调查危及生命的心律失常的触发原因并评估现有 ICD 的有效性。旨在加强基础生物医学和临床研究。预计 2000 名植入 ICD 的患者将参与该研究。电描记图 (EGM) 和 ICD 询问的相关数据已以专有数据格式存储在软盘上，该格式因设备制造商而异。目前，临床医生和研究人员必须使用不同的编程设备将数据绘制在纸上，以便查看和分析它们。对于该项目，我们正在开发定制软件，用于为 TOVA 研究创建自动化、基于网络且可搜索的 ICD EGM 和相关数据归档系统。该数据存档系统允许调查人员通过互联网远程上传 ICD 审讯数据。来自不同制造商的各种ICD模型的数据被自动转换成标准公共格式并插入数据库系统。研究人员可以通过网络查看和下载所有 EGM 波形、注释和设备设置参数。研究人员还可以记录任何 EGM 事件，并可以根据指定标准搜索特定患者或 EGM 事件。这个新的数据库系统是对 TOVA 项目的关键贡献，极大地加速了一直不令人满意的数据收集、组织和分析方法。该系统还有可能加速其他重要的研究项目，这些项目基于对与危及生命的室性心律失常相关的 EGM 特征的调查。