FREEZING OF GAIT, BRADYKINESIA & PARKINSONS DISEASE

步态冻结、运动迟缓

• 批准号: 7366526
• 负责人: JEFFREY M HAUSDORFF
• 金额: $ 0.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7366526
• 关键词: FREEZING; GAIT; BRADYKINESIA; PARKINSONS; DISEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pathophysiology of freezing of gait (FOG) and its relationship to other Parkinsonian symptoms is unclear. To gain insight into these motor disturbances, we assessed the relationship between FOG and other Parkinsonian features in Parkinson's disease (PD) and the response to levodopa. 19 PD patients with clinically significant FOG at "off" state were assessed while in "off" state, 12 hours after taking their anti-Parkinsonian medications, and while in "on" state, about 1 hour after their regular morning levodopa dose. Assessments included the Unified Parkinson's disease Rating Scale (UPDRS) and a 130 meter, videotaped walk. Three observers independently viewed the videotapes and scored FOG frequency. Parkinsonian features were analyzed by grouping together related UPDRS items. Inter-observer and intra-class reliability between the three observers were evaluated by Pearson and Friedman tests. Pearson correlation coefficients were used to assess the relationships between FOG and other Parkinsonian features. There was a high level of agreement between the three observers (R=0.7). FOG frequency was not correlated with severity of any other Parkinsonian features at "off" and only with speech and writing severity indexes at "on". FOG frequency was significantly decreased by levodopa treatment. This decrement was strongly correlated with improvement of tremor (R=0.80) and speech (R=0.62) indexes. No correlation was found between the response of FOG to levodopa and improvement in rigidity, bradykinesia, or balance indexes. Levodopa treatment decreases FOG frequency in PD patients. FOG is apparently an independent motor symptom of PD, caused by a paroxysmal pathology that is different from that responsible for bradykinesia, rigidity or postural instability. Ongoing research is aimed at understanding the mechanism of this characteristic gait disorder in PD.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。步态冻结（FOG）的病理生理及其与其他帕金森氏症状的关系尚不清楚。为了深入了解这些运动障碍，我们评估了FOG与帕金森氏病（PD）的其他帕金森氏症特征与对左旋多巴的反应之间的关系。在服用抗Parkinsonian药物后12小时，在“ OFF”状态下，在“ OFF”状态下评估了19例临床意义的PD患者，并在“ On”状态下，在常规早晨左旋多巴剂量后约1小时。评估包括统一的帕金森氏病评级量表（UPDRS）和130米的录像带。三位观察者独立观看了录像带并评分了雾频。通过将相关的UPDRS项目分组在一起，可以分析帕金森氏症功能。通过Pearson和Friedman测试评估了三个观察者之间的观察者间和阶层内可靠性。 Pearson相关系数用于评估雾与其他帕金森氏症特征之间的关系。三个观察者之间有很高的一致性（r = 0.7）。雾频频率与“ Off”的任何其他帕金森氏症特征的严重性无关，并且仅与“ on”的言语和写作严重性指数相关。左旋多巴处理可显着降低雾频。这种减少与震颤（r = 0.80）和语音（r = 0.62）索引的改善密切相关。在雾对左旋多巴的响应与刚性，胸肌或平衡指数的改善之间没有发现相关性。左旋多巴治疗可降低PD患者的雾频。雾显然是PD的独立运动症状，是由阵发性病理学引起的，其与负责头屈球，僵化或姿势不稳定的病理不同。正在进行的研究旨在了解PD中这种特征步态障碍的机制。