EFFECTS OF DUAL TASK ON GAIT INSTABILITY IN PARKINSONS DISEASE

双重任务对帕金森病步态不稳定性的影响

• 批准号: 7366524
• 负责人: JEFFREY M HAUSDORFF
• 金额: $ 0.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7366524
• 关键词: EFFECTS; DUAL; TASK; GAIT; INSTABILITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the incapacitating effects of falls, the specific factors that predispose patients with Parkinson's disease (PD) to falls remains elusive. Attention plays an important role in the gait disturbances of patients with Parkinson's disease. However, the effects of "dual tasking" on fall risk, in general, and, gait instability, more specifically, have not been well studied. To better understand the role of attention on gait in PD, we tested the hypothesis that gait variability increases when subjects with PD walk while performing a cognitively challenging task (CCT) and determined which PD features are associated with gait instability during dual task performance. Ten subjects with idiopathic PD walked on level ground while wearing force sensitive insoles under normal conditions and while performing a CCT. During normal walking, gait variability was significantly correlated with fall risk (r=.68), disease duration (r =.81), disease severity (r=. 84), motor function (r=.74), mentation, behavior and mood (r=.72) and cognitive function (r=-.64).During dual task walking, gait variability increased significantly. During dual task walking, the correlations between gait variability and patient characteristics were reduced; only disease duration remained significantly associated. These results highlight the profound effects of attention and "dual tasking" on walking and indicate that walking while cognitively challenged markedly exacerbates gait variability and impairs the ability of patients with PD to maintain a stable walk.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。尽管跌倒有致残作用，但导致帕金森氏病(PD)患者跌倒的具体因素仍不清楚。注意力在帕金森氏病患者的步态障碍中起着重要作用。然而，总的来说，“双重任务”对跌倒风险的影响，更具体地说，对步态不稳定的影响还没有得到很好的研究。为了更好地理解注意在帕金森病中的作用，我们检验了帕金森病患者在执行认知挑战任务(CCT)时步态变异性增加的假设，并确定了哪些帕金森病特征与双重任务执行期间的步态不稳定有关。10名特发性帕金森病患者在正常情况下穿着力敏感鞋垫在平地上行走，并进行CCT。在正常行走过程中，步态变异性与跌倒风险(r=.68)、病程(r=.81)、疾病严重程度(r=.运动功能(r=.74)、心理状态、行为和情绪(r=.72)和认知功能(r=-.64)。在双重任务步行过程中，步态变异性显著增加。在双重任务行走中，步态变异性与患者特征之间的相关性降低；只有病程仍然显著相关。这些结果突出了注意力和“双重任务”对行走的深刻影响，并表明在认知挑战的同时行走明显加剧了步态的变异性，并损害了帕金森病患者维持稳定行走的能力。