EFFECTS OF DUAL TASK ON GAIT INSTABILITY IN PARKINSONS DISEASE

双重任务对帕金森病步态不稳定性的影响

• 批准号: 7366524
• 负责人: JEFFREY M HAUSDORFF
• 金额: $ 0.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7366524
• 关键词: EFFECTS; DUAL; TASK; GAIT; INSTABILITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the incapacitating effects of falls, the specific factors that predispose patients with Parkinson's disease (PD) to falls remains elusive. Attention plays an important role in the gait disturbances of patients with Parkinson's disease. However, the effects of "dual tasking" on fall risk, in general, and, gait instability, more specifically, have not been well studied. To better understand the role of attention on gait in PD, we tested the hypothesis that gait variability increases when subjects with PD walk while performing a cognitively challenging task (CCT) and determined which PD features are associated with gait instability during dual task performance. Ten subjects with idiopathic PD walked on level ground while wearing force sensitive insoles under normal conditions and while performing a CCT. During normal walking, gait variability was significantly correlated with fall risk (r=.68), disease duration (r =.81), disease severity (r=. 84), motor function (r=.74), mentation, behavior and mood (r=.72) and cognitive function (r=-.64).During dual task walking, gait variability increased significantly. During dual task walking, the correlations between gait variability and patient characteristics were reduced; only disease duration remained significantly associated. These results highlight the profound effects of attention and "dual tasking" on walking and indicate that walking while cognitively challenged markedly exacerbates gait variability and impairs the ability of patients with PD to maintain a stable walk.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。尽管跌倒丧失作用，但使帕金森氏病（PD）患者跌倒的特定因素仍然难以捉摸。注意在帕金森氏病患者的步态障碍中起着重要作用。但是，“双重任务”对跌落风险的影响通常，更具体地说，步态不稳定性尚未得到很好的研究。为了更好地理解注意力在PD中的步态作用，我们检验了以下假设：在执行认知挑战性任务（CCT）的受试者时，步态变异性会增加，并确定哪些PD功能与双重任务性能期间的步态不稳定性相关。十名具有特发性PD的受试者在正常条件下佩戴力敏感的鞋垫，同时进行CCT时，在地面上行走。在正常步行期间，步态变异性与跌倒风险（r = .68），疾病持续时间（r = .81），疾病严重程度（r =。84），运动功能（r = .74），心理，行为和情绪（r = .72）和认知功能（r = - 。。。在双重任务步行期间，步态变异性与患者特征之间的相关性降低了；只有疾病持续时间保持显着相关。这些结果突出了注意力和“双重任务”对步行的深远影响，并表明步行在认知上挑战的同时显着加剧了步态的步态变异性，并损害了PD患者保持稳定行走的能力。