Integrating Data, Models, and Reasoning in Critical Care

描述（由申请人提供）：该生物工程研究合作伙伴关系的目标，成立于2003年10月，是开发和评估先进的ICU患者监测和决策支持系统，这将提高重症监护临床决策的效率，准确性和及时性。该合作伙伴关系结合了来自学术界（麻省理工学院），工业界（飞利浦医疗系统和飞利浦北美研究）和临床医学（贝斯以色列女执事医疗中心）的强大跨学科团队的资源。 在该BRP的初始资助期间，取得了实质性进展，包括开发了一个来自30，000多名ICU患者的大型新研究数据库（重症监护多参数智能监测（MIMIC）II数据库）以及一些有前途的先进监测概念和算法。我们的初步工作证实了这一假设，即对从ICU患者收集的丰富多参数数据进行复杂分析可以阐明他们不断变化的病理生理状态，甚至可以提供即将发生的状态变化的警报。 该BRP第二阶段的主要目标是利用MIMIC II的资源开发和证明先进监测概念和算法在实验室研究中的有效性，然后将成功的概念带入Beth Israel Deaconess Medical Center（BIDMC）的ICU和其他地方的临床试验中，与我们的临床和工业合作伙伴合作。我们还将通过增加新的成人和新生儿数据，设计和改进复杂的数据挖掘和信号处理工具，并通过PhysioNet（www.physiionet.org）向研究界免费分发数据库及其相关探索工具，来提高MIMIC II数据库的价值和可用性。 该生物工程研究伙伴关系成立于2003年10月，其目标是开发和评估先进的ICU患者监测和决策支持系统，以提高重症监护临床决策的效率、准确性和及时性。

DESCRIPTION (provided by applicant): The objective of this Bioengineering Research Partnership, established in October 2003, is to develop and evaluate advanced ICU patient monitoring and decision support systems that will improve the efficiency, accuracy, and timeliness of clinical decision-making in critical care. The partnership combines the resources of a powerful interdisciplinary team from academia (MIT), industry (Philips Medical Systems and Philips Research North America), and clinical medicine (Beth Israel Deaconess Medical Center). During the initial funding period of this BRP substantial progress has been achieved, including the development of a massive new research database from more than 30,000 ICU patients (the Multiparameter Intelligent Monitoring in Intensive Care (MIMIC) II database) and a number of promising advanced monitoring concepts and algorithms. Our initial work has substantiated the hypothesis that sophisticated analysis of the rich multi-parameter data gathered from ICU patients can illuminate their changing pathophysiologic state, and can even provide alerts of impending changes in state. The major goals for the second phase of this BRP are to develop and demonstrate the effectiveness of advanced monitoring concepts and algorithms in laboratory studies utilizing the resources of MIMIC II, and then to carry successful concepts forward into clinical tests in the ICUs of Beth Israel Deaconess Medical Center (BIDMC) and elsewhere with the collaboration of our clinical and industrial partners. We also will enhance the value and availability of the MIMIC II database by adding new adult and neonatal data, designing and improving sophisticated data mining and signal processing tools, and freely distributing to the research community the database and its associated exploration tools via PhysioNet (www.physiionet.org). PUBLIC HEALTH RELEVANCE The objective of this Bioengineering Research Partnership, established in October 2003, is to develop and evaluate advanced ICU patient monitoring and decision support systems that will improve the efficiency, accuracy, and timeliness of clinical decision-making in critical care.