SIGNAL TRANSDUCTION MECHANISMS OF CELL-SURFACE LIGAND-RECEPTOR SYSTEMS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们研究了细胞表面受体的结构及其与细胞外配体的复合物，以了解跨质膜信号转导的分子机制。研究中的受体-配体系统包括Eh-受体/肝配蛋白、神经纤毛蛋白/脑信号蛋白和Tie/血管生成素。这些参与调节发育和成人的神经和心血管系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We study the structures of cell-surface receptors and their complexes with extracellular ligands in order to understand the molecular mechanisms of signal transduction across the plasma membrane. The receptor-ligand systems under investigation include Eph-receptors/ephrins, Neuropilins/Semaphorins, and Tie/Angiopoietins. These are involved in regulating the developing and adult nervous and cardiovascular systems.