SIGNAL TRANSDUCTION MECHANISMS OF CELL-SURFACE LIGAND-RECEPTOR SYSTEMS

细胞表面配体受体系统的信号转导机制

• 批准号: 7721231
• 负责人: DIMITAR B NIKOLOV
• 金额: $ 0.7万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721231
• 关键词: Adult; Angiopoietins; Cardiovascular system; Cell Surface Receptors; Cell membrane; Cell surface; Complex; Computer Retrieval of Information on Scientific Projects Database; Eph Family Receptors; EphA1 Receptor; Ephrins; Funding; Grant; Institution; Investigation; Ligands; Molecular; Neuropilins; Research; Research Personnel; Resources; Semaphorins; Signal Transduction; Source; Structure; System; United States National Institutes of Health; extracellular; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We study the structures of cell-surface receptors and their complexes with extracellular ligands in order to understand the molecular mechanisms of signal transduction across the plasma membrane. The receptor-ligand systems under investigation include Eph-receptors/ephrins, Neuropilins/Semaphorins, and Tie/Angiopoietins. These are involved in regulating the developing and adult nervous and cardiovascular systems.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们研究细胞表面受体及其与胞外配体的复合体的结构，以了解跨质膜信号转导的分子机制。正在研究的受体-配体系统包括Eph-受体/eaffins、Neuropilins/信号素和Tie/Angiopoietins。它们参与调节发育中的和成人的神经和心血管系统。