SIGNAL TRANSDUCTION MECHANISMS OF CELL-SURFACE LIGAND-RECEPTOR SYSTEMS

细胞表面配体受体系统的信号转导机制

• 批准号: 7721231
• 负责人: DIMITAR B NIKOLOV
• 金额: $ 0.7万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721231
• 关键词: Adult; Angiopoietins; Cardiovascular system; Cell Surface Receptors; Cell membrane; Cell surface; Complex; Computer Retrieval of Information on Scientific Projects Database; Eph Family Receptors; EphA1 Receptor; Ephrins; Funding; Grant; Institution; Investigation; Ligands; Molecular; Neuropilins; Research; Research Personnel; Resources; Semaphorins; Signal Transduction; Source; Structure; System; United States National Institutes of Health; extracellular; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We study the structures of cell-surface receptors and their complexes with extracellular ligands in order to understand the molecular mechanisms of signal transduction across the plasma membrane. The receptor-ligand systems under investigation include Eph-receptors/ephrins, Neuropilins/Semaphorins, and Tie/Angiopoietins. These are involved in regulating the developing and adult nervous and cardiovascular systems.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们研究细胞表面受体及其与细胞外配体的复合物的结构，以了解整个质膜的信号转导的分子机制。正在研究的受体配体系统包括EPH受体/ephrins，Neuropilins/Semaphorins和TIE/Angiopoietins。这些参与调节发展中的和成人的神经和心血管系统。