STRUCTURAL STUDIES OF EPH RECEPTORS AND EPHRINS

EPH 受体和 EHRINS 的结构研究

• 批准号: 8169221
• 负责人: DIMITAR B NIKOLOV
• 金额: $ 4.36万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169221
• 关键词: Binding; Biochemical; Computer Retrieval of Information on Scientific Projects Database; Eph Family Receptors; Ephrins; Funding; Grant; Henipavirus; Institution; Ligands; Methods; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; X-Ray Crystallography; cell attachment protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We use X-ray crystallography, combined with other biophysical and biochemical methods, to study the structure and function of the Eph receptors and their interactions with the ephrin ligands. We also study the interactions of Ephs and ephrins with other binding partners, including the Henipavirus cell-attachment proteins.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们使用X射线晶体学，并结合其他生物物理和生化方法来研究EPH受体的结构和功能及其与Ephrin配体的相互作用。 我们还研究了Ephs和Ephrins与其他结合伴侣的相互作用，包括HENIPAVIRUS细胞跟踪蛋白。