STRUCTURAL STUDIES OF EPH RECEPTORS AND EPHRINS

EPH 受体和 EHRINS 的结构研究

• 批准号: 8169221
• 负责人: DIMITAR B NIKOLOV
• 金额: $ 4.36万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169221
• 关键词: Binding; Biochemical; Computer Retrieval of Information on Scientific Projects Database; Eph Family Receptors; Ephrins; Funding; Grant; Henipavirus; Institution; Ligands; Methods; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; X-Ray Crystallography; cell attachment protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We use X-ray crystallography, combined with other biophysical and biochemical methods, to study the structure and function of the Eph receptors and their interactions with the ephrin ligands. We also study the interactions of Ephs and ephrins with other binding partners, including the Henipavirus cell-attachment proteins.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们使用X射线结晶学，结合其他生物物理和生化方法，研究Eph受体的结构和功能以及它们与Ephin配体的相互作用。我们还研究了Ephs和Ephins与其他结合伙伴的相互作用，包括HenipaVirus细胞附着蛋白。