STRUCTURAL STUDIES OF EPH RECEPTORS AND EPHRINS

EPH 受体和 EHRINS 的结构研究

• 批准号: 8361611
• 负责人: DIMITAR B NIKOLOV
• 金额: $ 3.47万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361611
• 关键词: Binding; Biochemical; Eph Family Receptors; Ephrins; Funding; Grant; Henipavirus; Ligands; Methods; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Structure; United States National Institutes of Health; X-Ray Crystallography; cell attachment protein; cost; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We use X-ray crystallography, combined with other biophysical and biochemical methods, to study the structure and function of the Eph receptors and their interactions with the ephrin ligands. We also study the interactions of Ephs and ephrins with other binding partners, including the Henipavirus cell-attachment proteins.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们使用X射线晶体学，并结合其他生物物理和生化方法来研究EPH受体的结构和功能及其与Ephrin配体的相互作用。 我们还研究了Ephs和Ephrins与其他结合伴侣的相互作用，包括HENIPAVIRUS细胞跟踪蛋白。