Study of Atherosclerotic Risk in an Overweight Latino Adolescent Population

描述（申请人提供）：太阳能的目标（拉丁裔青少年风险研究）糖尿病项目，DK 59211，旨在评估导致超重西班牙裔儿童青春期生长发育期间胰岛素抵抗和代偿性β细胞功能的因素，并检查胰岛素作用变化的潜在机制，胰岛素分泌和β细胞功能在2型糖尿病和心血管风险的进展在这一关键时期。Goran博士指导的这项纵向研究解决了超重拉丁裔儿童的一个关键的青少年健康问题，并可能为预防策略奠定基础。在这四年中获得的大量信息帮助我们更好地理解了超重西班牙裔儿童血糖调节的因素，并作为重新制定 我们的一些假设和研究方向，引导我们实现当前应用的目标。根据SOLAR研究的观察结果，我们报告10名儿童中有9名至少有1种风险 在心血管疾病和/或2型糖尿病的危险因素中，30%的人有3个或更多的危险因素（即代谢综合征），代谢综合征的程度与胰岛素抵抗有关。基于这些观察，本申请的长期目标是检查代谢综合征与2型糖尿病的发展和心血管疾病进展之间的关系。为此，我们通过B超测量颈总动脉内膜中层厚度，这是早期动脉粥样硬化的非侵入性标志物。该应用程序的具体目标是：1）通过CCA-IMT测量超重拉丁裔青少年的横断面样本，确定肥胖和代谢参数的相关性，2）通过CCA-IMT测量，评估可能导致早期动脉粥样硬化的肥胖和代谢风险的纵向变化，（3）用不同的肥胖和代谢风险指标对CCA-IMT进行重复测量。公共卫生相关性：这项研究的相关性是为公共卫生专业人员提供关于极高风险青少年人群心血管风险的宝贵和关键信息。然后，这些知识将被用来创建有效的干预措施和/或设计新的临床方法，对拉丁美洲超重青年的心血管评价，从而改善健康，伴随肥胖和2型糖尿病的预防。

DESCRIPTION (provided by applicant): The objective of the SOLAR (Study of Latino Adolescents at Risk) Diabetes Project, DK 59211, is to evaluate factors contributing to insulin resistance and compensatory beta-cell function in overweight Hispanic children during pubertal growth and development, and to examine mechanisms underlying changes in insulin action, insulin secretion and beta-cell function in the progression of type 2 diabetes and cardiovascular risk during this critical period. This longitudinal study directed by Dr. Goran addresses a critical adolescent health problem in overweight Latino children and may lay the foundation for prevention strategies. The wealth of information obtained during the four years has helped us to better understand factors contributing to glucose regulation in overweight Hispanic children and has served as the basis for reformulating some of our hypotheses and research directions, leading us to the objectives of the current application. Based on observations of the SOLAR study, we reported 9 out of 10 children had at least 1 risk factor for cardiovascular disease and/or type 2 diabetes, 30% had clustering of 3 or more risk factors (i.e. metabolic syndrome), and the extent of the metabolic syndrome was related to insulin resistance. Based on these observations, the current application's long-term objective is to examine the relationship between the metabolic syndrome and development of type 2 diabetes and cardiovascular disease progression. To this end,, we are measuring intima media thickness of the common carotid artery via B-mode ultrasonography, a non-invasive marker of early atherosclerosis. The specific aims of the application are: 1) To determine the associations in adiposity and metabolic parameters by CCA-IMT measurement in a cross-sectional sample of overweight Latino adolescents, 2) To assess the longitudinal changes in adiposity and metabolic risk that could be contributory to early atherosclerosis, as measured by CCA-IMT, and 3) To examine the repeated measures of CCA-IMT with various measures of adiposity and metabolic risk. PUBLIC HEALTH RELEVANCE: The relevance of this study is to give public health professionals valuable and critical information regarding cardiovascular risks to an extremely high-risk adolescent population. This knowledge will then be utilized to either create effective interventions and/or to devise new clinical methodologies regarding cardiovascular evaluations on Latino overweight youth, thus improving health, concomitant with obesity and type 2 diabetes prevention.